Research ArticleArticle
Naproxen Effects on Brain Response to Painful Pressure Stimulation in Patients with Knee Osteoarthritis: A Double-blind, Randomized, Placebo-controlled, Single-dose Study
Mónica Giménez, Jesús Pujol, Zahid Ali, Marina López-Solà, Oren Contreras-Rodríguez, Joan Deus, Héctor Ortiz, Carles Soriano-Mas, Jone Llorente-Onaindia and Jordi Monfort
The Journal of Rheumatology October 2014, jrheum.131367; DOI: https://doi.org/10.3899/jrheum.131367
Mónica Giménez
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
Jesús Pujol
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
Zahid Ali
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
Marina López-Solà
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
Oren Contreras-Rodríguez
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
Joan Deus
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
Héctor Ortiz
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
Carles Soriano-Mas
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
Jone Llorente-Onaindia
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
Jordi Monfort
From the MRI Research Unit, CRC Mar; Rheumatology Department, Hospital del Mar; Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Department of Clinical and Health Psychology, Autonomous University of Barcelona; Bellvitge Biomedical Research Institute, Psychiatry Department, Bellvitge University Hospital, CYBERSAM; Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain; Neurosciences Centers of Excellence for Drug Discovery (CEDD), GlaxoSmithKline, London, UK; Pfizer, Neusentis, Cambridge, UK; Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. Supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by the Neuroscience CEDD, GlaxoSmithKline. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government. M. López-Solà is supported by the postdoctoral fellowship Beatriu de Pinós, awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR) from the Catalan Government (2010 BP_A 00136). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). M. Giménez, PhD; O. Contreras-Rodríguez, PhD; H. Ortiz, MsC, MRI Research Unit, CRC Mar, Hospital del Mar; J. Pujol, MD, MRI Research Unit, CRC Mar, Hospital del Mar, Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21; Z. Ali, PhD, Neurosciences CEDD, GlaxoSmithKline; M. López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Psychology and Neuroscience, University of Colorado; J. Deus, PhD, MRI Research Unit, CRC Mar, Hospital del Mar, Department of Clinical and Health Psychology, Autonomous University of Barcelona; C. Soriano-Mas, PhD, Bellvitge Biomedical Research Institute-IDIBELL, Psychiatry Department, Bellvitge University Hospital, CIBERSAM; J. Llorente-Onaindia, MsC; J. Monfort, MD, PhD, Rheumatology Department, Hospital del Mar, Cell Research Group in Inflammation and Cartilage, Institut Hospital del Mar d’Investigacions Mèdiques. Address correspondence to Dr. J. Pujol, Department of Magnetic Resonance, CRC-Mar, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. E-mail: 21404jpn@comb.cat. Accepted for publication July 24, 2014.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Naproxen Effects on Brain Response to Painful Pressure Stimulation in Patients with Knee Osteoarthritis: A Double-blind, Randomized, Placebo-controlled, Single-dose Study
Mónica Giménez, Jesús Pujol, Zahid Ali, Marina López-Solà, Oren Contreras-Rodríguez, Joan Deus, Héctor Ortiz, Carles Soriano-Mas, Jone Llorente-Onaindia, Jordi Monfort
The Journal of Rheumatology Oct 2014, jrheum.131367; DOI: 10.3899/jrheum.131367
Naproxen Effects on Brain Response to Painful Pressure Stimulation in Patients with Knee Osteoarthritis: A Double-blind, Randomized, Placebo-controlled, Single-dose Study
Mónica Giménez, Jesús Pujol, Zahid Ali, Marina López-Solà, Oren Contreras-Rodríguez, Joan Deus, Héctor Ortiz, Carles Soriano-Mas, Jone Llorente-Onaindia, Jordi Monfort
The Journal of Rheumatology Oct 2014, jrheum.131367; DOI: 10.3899/jrheum.131367