Research ArticleArticle
Common Variants of cGKII/PRKG2 Are Not Associated with Gout Susceptibility
Masayuki Sakiyama, Hirotaka Matsuo, Toshinori Chiba, Akiyoshi Nakayama, Takahiro Nakamura, Seiko Shimizu, Emi Morita, Nana Fukuda, Hiroshi Nakashima, Yutaka Sakurai, Kimiyoshi Ichida, Toru Shimizu and Nariyoshi Shinomiya
The Journal of Rheumatology June 2014, jrheum.131548; DOI: https://doi.org/10.3899/jrheum.131548
Masayuki Sakiyama
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Hirotaka Matsuo
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Toshinori Chiba
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Akiyoshi Nakayama
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Takahiro Nakamura
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Seiko Shimizu
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Emi Morita
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Nana Fukuda
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Hiroshi Nakashima
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Yutaka Sakurai
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Kimiyoshi Ichida
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Toru Shimizu
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
Nariyoshi Shinomiya
Department From the Department of Dermatology, of Integrative Laboratory Physiology for Mathematics, and Bio-Nano and Medicine, Department of Preventive Medicine and Public Health, National Defense Nagoya Pathophysiology, Medical University College, Tokorozawa; Tokyo Graduate University School Department ofof Pharmacy Medicine, of Preventive and Nagoya; Life Sciences, Medicine, Department Tokyo; of Division of Kidney and Hypertension, Department of Internal Medicine, Jikei Takatsuki, University Japan. School of Medicine, Tokyo; and Midorigaoka Hospital, Supported of Japan; the by Ministry grants from of Health, the Ministry Labor, of and Education, Welfare Science, of Japan; and the Culture Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation Grant; the Takeda for Promotion Science of Foundation; Pediatrics; and the the AstraZeneca Gout Research VRI Research Foundation of Japan. M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical Department College; H. of Matsuo, Integrative MD, PhD; Physiology T. Chiba, andMD; Bio-Nano A. Nakayama, Medicine, MD, National Mathematics, Defense Medical National College; Defense T. Nakamura, Medical PhD, College; Laboratory S. Shimizu, for PhD, Department Defense Department Medical of of Integrative Preventive College; Medicine, E. Physiology Morita,Nagoya MD, and PhD; Bio-Nano University N. Fukuda, Medicine, Graduate BHE, National School of of Preventive Medicine; H. Medicine Nakashima, and Public MD, PhD; Health, Y. Sakurai, National MD, Defense PhD, Medical Department University Hypertension, College; of Medicine; K. of Ichida, T. Pharmacy Department Shimizu, MD, and MD, PhD, of Life Internal PhD, Department Sciences; Midorigaoka Medicine, of Division Pathophysiology, Jikei Hospital; of University Kidney N. Shinomiya, and Tokyo School MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. Drs. Sakiyama and Matsuo contributed equally to this work. Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo@ndmc.ac.jp Accepted for publication March 14, 2014.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Common Variants of cGKII/PRKG2 Are Not Associated with Gout Susceptibility
Masayuki Sakiyama, Hirotaka Matsuo, Toshinori Chiba, Akiyoshi Nakayama, Takahiro Nakamura, Seiko Shimizu, Emi Morita, Nana Fukuda, Hiroshi Nakashima, Yutaka Sakurai, Kimiyoshi Ichida, Toru Shimizu, Nariyoshi Shinomiya
The Journal of Rheumatology Jun 2014, jrheum.131548; DOI: 10.3899/jrheum.131548
Common Variants of cGKII/PRKG2 Are Not Associated with Gout Susceptibility
Masayuki Sakiyama, Hirotaka Matsuo, Toshinori Chiba, Akiyoshi Nakayama, Takahiro Nakamura, Seiko Shimizu, Emi Morita, Nana Fukuda, Hiroshi Nakashima, Yutaka Sakurai, Kimiyoshi Ichida, Toru Shimizu, Nariyoshi Shinomiya
The Journal of Rheumatology Jun 2014, jrheum.131548; DOI: 10.3899/jrheum.131548