Research ArticleArticle
Comparison of Labial Minor Salivary Gland Biopsies from Childhood Sjögren Syndrome and Age-matched Controls
Naoto Yokogawa, Scott M. Lieberman, Faizan Alawi, Sharon Bout-Tabaku, Marta Guttenberg, David D. Sherry and Frederick B. Vivino
The Journal of Rheumatology May 2014, jrheum.131511; DOI: https://doi.org/10.3899/jrheum.131511
Naoto Yokogawa
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children’s Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. Dr. Yokogawa and Dr. Lieberman contributed equally to this study. Address correspondence to Dr. S.M. Lieberman, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191A ML, Iowa City, Iowa 52242, USA. E-mail: scott-lieberman@uiowa.edu. Accepted for publication February 28, 2014.
Scott M. Lieberman
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children’s Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. Dr. Yokogawa and Dr. Lieberman contributed equally to this study. Address correspondence to Dr. S.M. Lieberman, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191A ML, Iowa City, Iowa 52242, USA. E-mail: scott-lieberman@uiowa.edu. Accepted for publication February 28, 2014.
Faizan Alawi
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children’s Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. Dr. Yokogawa and Dr. Lieberman contributed equally to this study. Address correspondence to Dr. S.M. Lieberman, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191A ML, Iowa City, Iowa 52242, USA. E-mail: scott-lieberman@uiowa.edu. Accepted for publication February 28, 2014.
Sharon Bout-Tabaku
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children’s Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. Dr. Yokogawa and Dr. Lieberman contributed equally to this study. Address correspondence to Dr. S.M. Lieberman, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191A ML, Iowa City, Iowa 52242, USA. E-mail: scott-lieberman@uiowa.edu. Accepted for publication February 28, 2014.
Marta Guttenberg
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children’s Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. Dr. Yokogawa and Dr. Lieberman contributed equally to this study. Address correspondence to Dr. S.M. Lieberman, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191A ML, Iowa City, Iowa 52242, USA. E-mail: scott-lieberman@uiowa.edu. Accepted for publication February 28, 2014.
David D. Sherry
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children’s Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. Dr. Yokogawa and Dr. Lieberman contributed equally to this study. Address correspondence to Dr. S.M. Lieberman, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191A ML, Iowa City, Iowa 52242, USA. E-mail: scott-lieberman@uiowa.edu. Accepted for publication February 28, 2014.
Frederick B. Vivino
From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children’s Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. Dr. Yokogawa and Dr. Lieberman contributed equally to this study. Address correspondence to Dr. S.M. Lieberman, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191A ML, Iowa City, Iowa 52242, USA. E-mail: scott-lieberman@uiowa.edu. Accepted for publication February 28, 2014.
Abstract
Objective To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS).
Methods Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist.
Results The presence of any focal sialadenitis (focus score > 0 foci/4 mm2) was common among childhood SS samples but present in only 1 of 8 control samples.
Conclusion The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Comparison of Labial Minor Salivary Gland Biopsies from Childhood Sjögren Syndrome and Age-matched Controls
Naoto Yokogawa, Scott M. Lieberman, Faizan Alawi, Sharon Bout-Tabaku, Marta Guttenberg, David D. Sherry, Frederick B. Vivino
The Journal of Rheumatology May 2014, jrheum.131511; DOI: 10.3899/jrheum.131511
Comparison of Labial Minor Salivary Gland Biopsies from Childhood Sjögren Syndrome and Age-matched Controls
Naoto Yokogawa, Scott M. Lieberman, Faizan Alawi, Sharon Bout-Tabaku, Marta Guttenberg, David D. Sherry, Frederick B. Vivino
The Journal of Rheumatology May 2014, jrheum.131511; DOI: 10.3899/jrheum.131511