Research ArticleArticle
Clinically Inactive Disease in a Cohort of Children with New-onset Polyarticular Juvenile Idiopathic Arthritis Treated with Early Aggressive Therapy: Time to Achievement, Total Duration, and Predictors
Carol A. Wallace, Edward H. Giannini, Steven J. Spalding, Philip J. Hashkes, Kathleen M. O’Neil, Andrew S. Zeft, Ilona S. Szer, Sarah Ringold, Hermine I. Brunner, Laura E. Schanberg, Robert P. Sundel, Diana S. Milojevic, Marilynn G. Punaro, Peter Chira, Beth S. Gottlieb, Gloria C. Higgins, Norman T. Ilowite, Yukiko Kimura, Anne Johnson, Bin Huang and Daniel J. Lovell
The Journal of Rheumatology May 2014, jrheum.131503; DOI: https://doi.org/10.3899/jrheum.131503
Carol A. Wallace
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Edward H. Giannini
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Steven J. Spalding
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Philip J. Hashkes
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Kathleen M. O’Neil
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Andrew S. Zeft
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Ilona S. Szer
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Sarah Ringold
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Hermine I. Brunner
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Laura E. Schanberg
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Robert P. Sundel
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Diana S. Milojevic
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Marilynn G. Punaro
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Peter Chira
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Beth S. Gottlieb
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Gloria C. Higgins
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Norman T. Ilowite
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Yukiko Kimura
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Anne Johnson
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Bin Huang
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Daniel J. Lovell
From the Seattle Children’s Hospital and Research Institute, Seattle, Washington; Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati; Cleveland Clinic, Cleveland, Ohio, USA; Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indianapolis; Rady Children’s Hospital, San Diego, California; Duke University Medical Center, Durham, North Carolina; Children’s Hospital of Boston; Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts; Department of Pediatrics, Texas Scottish Rite Hospital, Dallas, Texas; Hofstra North Shore-LIJ School of Medicine, New York, New York; Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio; Children’s Hospital at Montefiore, New York, New York; Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by US National Institutes of Health Grants: 1RO1 AR049762-01A2, 3R01AR049762-04S1, P60 AR047784-07, the Howe Endowment for Juvenile Rheumatoid Arthritis Research. Support for medication and placebo for the original trial from Amgen. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children’s Hospital and Research Institute; E.H. Giannini, MSc, DrPH; H.I. Brunner, MD, MSc, MBA, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine; S.J. Spalding, MD, Cleveland Clinic; P.J. Hashkes, MD, MSc, Shaare Zedek Medical Center; K.M. O’Neil, MD, Riley Hospital for Children, Indiana University School of Medicine; A.S. Zeft, MD, Cleveland Clinic; I.S. Szer, MD, Rady Children’s Hospital; L.E. Schanberg, MD, Duke University Medical Center; R.P. Sundel, MD, Children’s Hospital of Boston; D. Milojevic, MD, Floating Hospital for Children, Tufts Medical Center; M.G. Punaro, MD, Texas Scottish Rite Hospital; P. Chira, MD, Riley Hospital for Children, Indiana University School of Medicine; B.S. Gottlieb, MD, MS, Hofstra North Shore-LIJ School of Medicine; G.C. Higgins, PhD, MD, The Ohio State University and Nationwide Children’s Hospital; N.T. Ilowite, MD, Children’s Hospital at Montefiore; Y. Kimura, MD, Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center; A. Johnson, CCRP; B. Huang, PhD, Cincinnati Children’s Hospital Medical Center; D.J. Lovell, MD, MPH, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine. Address correspondence to Dr. Wallace, Division of Rheumatology, University of Washington and Seattle Children’s Hospital and Research Institute, 4800 Sand Point Way NE, MA.7.110, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication February 28, 2014.
Roles: for the Childhood Arthritis and Rheumatology Research Alliance (CARRA)
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Clinically Inactive Disease in a Cohort of Children with New-onset Polyarticular Juvenile Idiopathic Arthritis Treated with Early Aggressive Therapy: Time to Achievement, Total Duration, and Predictors
Carol A. Wallace, Edward H. Giannini, Steven J. Spalding, Philip J. Hashkes, Kathleen M. O’Neil, Andrew S. Zeft, Ilona S. Szer, Sarah Ringold, Hermine I. Brunner, Laura E. Schanberg, Robert P. Sundel, Diana S. Milojevic, Marilynn G. Punaro, Peter Chira, Beth S. Gottlieb, Gloria C. Higgins, Norman T. Ilowite, Yukiko Kimura, Anne Johnson, Bin Huang, Daniel J. Lovell
The Journal of Rheumatology May 2014, jrheum.131503; DOI: 10.3899/jrheum.131503
Clinically Inactive Disease in a Cohort of Children with New-onset Polyarticular Juvenile Idiopathic Arthritis Treated with Early Aggressive Therapy: Time to Achievement, Total Duration, and Predictors
Carol A. Wallace, Edward H. Giannini, Steven J. Spalding, Philip J. Hashkes, Kathleen M. O’Neil, Andrew S. Zeft, Ilona S. Szer, Sarah Ringold, Hermine I. Brunner, Laura E. Schanberg, Robert P. Sundel, Diana S. Milojevic, Marilynn G. Punaro, Peter Chira, Beth S. Gottlieb, Gloria C. Higgins, Norman T. Ilowite, Yukiko Kimura, Anne Johnson, Bin Huang, Daniel J. Lovell
The Journal of Rheumatology May 2014, jrheum.131503; DOI: 10.3899/jrheum.131503