Research ArticleArticle
Folic Acid and Folinic Acid for Reducing Side Effects in Patients Receiving Methotrexate for Rheumatoid Arthritis
Beverley Shea, Michael V. Swinden, Elizabeth Tanjong Ghogomu, Zulma Ortiz, Wanruchada Katchamart, Tamara Rader, Claire Bombardier, George A. Wells and Peter Tugwell
The Journal of Rheumatology April 2014, jrheum.130738; DOI: https://doi.org/10.3899/jrheum.130738
Beverley Shea
From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information). Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review. B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program. Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca. Accepted for publication January 31, 2014.
Michael V. Swinden
From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information). Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review. B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program. Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca. Accepted for publication January 31, 2014.
Elizabeth Tanjong Ghogomu
From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information). Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review. B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program. Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca. Accepted for publication January 31, 2014.
Zulma Ortiz
From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information). Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review. B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program. Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca. Accepted for publication January 31, 2014.
Wanruchada Katchamart
From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information). Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review. B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program. Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca. Accepted for publication January 31, 2014.
Tamara Rader
From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information). Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review. B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program. Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca. Accepted for publication January 31, 2014.
Claire Bombardier
From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information). Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review. B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program. Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca. Accepted for publication January 31, 2014.
George A. Wells
From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information). Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review. B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program. Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca. Accepted for publication January 31, 2014.
Peter Tugwell
From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information). Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review. B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program. Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca. Accepted for publication January 31, 2014.
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- Published online April 15, 2014.
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© 2014 The Journal of Rheumatology
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- Beverley Shea,
- Michael V. Swinden,
- Elizabeth Tanjong Ghogomu,
- Zulma Ortiz,
- Wanruchada Katchamart,
- Tamara Rader,
- Claire Bombardier,
- George A. Wells and
- Peter Tugwell
- From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada.
This report is based on a Cochrane review published in The Cochrane Library 2013, Issue 5 (see www.thecochranelibrary.com for information).
Cochrane reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review.
B. Shea, PhD, MSc, RN, BRI, Department of Epidemiology and Community Medicine, University of Ottawa; M.V. Swinden, MBBS; E. Tanjong Ghogomu, MD, MSc, Centre for Global Health, Institute of Population Health, University of Ottawa; Z. Ortiz, MD, MSc, Epidemiological Research Center, National Academy of Medicine; W. Katchamart, MD, FRCP, MSc, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University; T. Rader, MLIS, Cochrane Musculoskeletal Group; C. Bombardier, MD, FRCPC, Institute for Work and Health; G.A. Wells, PhD, MSc, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, FRCPC, MSc, Department of Medicine, Faculty of Medicine, Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa; and Ottawa Hospital Research Institute, Clinical Epidemiology Program.
Address correspondence to B. Shea, Bruyère Research Institute, 85 Primrose, Ottawa, ON K1R 6M1, Canada. E-mail: bevshea@uottawa.ca.
Accepted for publication January 31, 2014.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Folic Acid and Folinic Acid for Reducing Side Effects in Patients Receiving Methotrexate for Rheumatoid Arthritis
Beverley Shea, Michael V. Swinden, Elizabeth Tanjong Ghogomu, Zulma Ortiz, Wanruchada Katchamart, Tamara Rader, Claire Bombardier, George A. Wells, Peter Tugwell
The Journal of Rheumatology Apr 2014, jrheum.130738; DOI: 10.3899/jrheum.130738
Folic Acid and Folinic Acid for Reducing Side Effects in Patients Receiving Methotrexate for Rheumatoid Arthritis
Beverley Shea, Michael V. Swinden, Elizabeth Tanjong Ghogomu, Zulma Ortiz, Wanruchada Katchamart, Tamara Rader, Claire Bombardier, George A. Wells, Peter Tugwell
The Journal of Rheumatology Apr 2014, jrheum.130738; DOI: 10.3899/jrheum.130738