Research ArticleArticle
Associations Between Biomarkers of Joint Metabolism, Hand Osteoarthritis, and Hand Pain and Function: The Johnston County Osteoarthritis Project
Imran Aslam, Irina Perjar, Xiaoyan A. Shi, Jordan B. Renner, Virginia B. Kraus, Yvonne M. Golightly, Joanne M. Jordan and Amanda E. Nelson
The Journal of Rheumatology March 2014, jrheum.130904; DOI: https://doi.org/10.3899/jrheum.130904
Imran Aslam
From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA. Funded in part by: Aslam/Perjar: American Geriatrics Society Medical Student Training in Aging Research (MSTAR) program; Perjar: American College of Rheumatology/Rheumatology Research Foundation Medical Student Research Preceptorship; Kraus: US National Institutes of Health (NIH)/National Institute on Aging Claude D. Pepper Older American Independence Centers P60 AG11268 and P30 AG028716, NIH/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) U01 AR050898; Jordan/Renner: US Centers for Disease Control and Prevention/Association of Schools of Public Health S043 and S3486, NIH/NIAMS Multidisciplinary Clinical Research Centers P60 AR49465; Golightly: Arthritis Foundation Postdoctoral Fellowship Award; Nelson: NIH/NIAMS K23 AR061406. I. Aslam, BS, medical student, Northeast Ohio Medical School; I. Perjar, BA, medical student, University of North Carolina at Chapel Hill School of Medicine; X.A. Shi, PhD, staff statistician, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, and SAS Institute; J.B. Renner, MD, Professor, Department of Radiology, Thurston Arthritis Research Center and Department of Radiology, University of North Carolina at Chapel Hill; V.B. Kraus, MD, PhD, Professor of Medicine and Pathology, Associate Professor in Surgery, Duke University School of Medicine; Y.M. Golightly, PT, PhD, Assistant Professor of Epidemiology, Thurston Arthritis Research Center, and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill; J.M. Jordan, MD, MPH, Professor of Medicine and Orthopedics, Adjunct Professor of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Department of Epidemiology, Gillings School of Global Public Health, Department of Orthopedics, University of North Carolina at Chapel Hill; A.E. Nelson, MD, MSCR, Assistant Professor of Medicine, School of Medicine, and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill. Address correspondence to Dr. A.E. Nelson, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, CB #7280, Chapel Hill, North Carolina 27599-7280, USA. E-mail: aenelson@med.unc.edu. Accepted for publication November 19, 2013.
Irina Perjar
From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA. Funded in part by: Aslam/Perjar: American Geriatrics Society Medical Student Training in Aging Research (MSTAR) program; Perjar: American College of Rheumatology/Rheumatology Research Foundation Medical Student Research Preceptorship; Kraus: US National Institutes of Health (NIH)/National Institute on Aging Claude D. Pepper Older American Independence Centers P60 AG11268 and P30 AG028716, NIH/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) U01 AR050898; Jordan/Renner: US Centers for Disease Control and Prevention/Association of Schools of Public Health S043 and S3486, NIH/NIAMS Multidisciplinary Clinical Research Centers P60 AR49465; Golightly: Arthritis Foundation Postdoctoral Fellowship Award; Nelson: NIH/NIAMS K23 AR061406. I. Aslam, BS, medical student, Northeast Ohio Medical School; I. Perjar, BA, medical student, University of North Carolina at Chapel Hill School of Medicine; X.A. Shi, PhD, staff statistician, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, and SAS Institute; J.B. Renner, MD, Professor, Department of Radiology, Thurston Arthritis Research Center and Department of Radiology, University of North Carolina at Chapel Hill; V.B. Kraus, MD, PhD, Professor of Medicine and Pathology, Associate Professor in Surgery, Duke University School of Medicine; Y.M. Golightly, PT, PhD, Assistant Professor of Epidemiology, Thurston Arthritis Research Center, and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill; J.M. Jordan, MD, MPH, Professor of Medicine and Orthopedics, Adjunct Professor of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Department of Epidemiology, Gillings School of Global Public Health, Department of Orthopedics, University of North Carolina at Chapel Hill; A.E. Nelson, MD, MSCR, Assistant Professor of Medicine, School of Medicine, and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill. Address correspondence to Dr. A.E. Nelson, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, CB #7280, Chapel Hill, North Carolina 27599-7280, USA. E-mail: aenelson@med.unc.edu. Accepted for publication November 19, 2013.
Xiaoyan A. Shi
From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA. Funded in part by: Aslam/Perjar: American Geriatrics Society Medical Student Training in Aging Research (MSTAR) program; Perjar: American College of Rheumatology/Rheumatology Research Foundation Medical Student Research Preceptorship; Kraus: US National Institutes of Health (NIH)/National Institute on Aging Claude D. Pepper Older American Independence Centers P60 AG11268 and P30 AG028716, NIH/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) U01 AR050898; Jordan/Renner: US Centers for Disease Control and Prevention/Association of Schools of Public Health S043 and S3486, NIH/NIAMS Multidisciplinary Clinical Research Centers P60 AR49465; Golightly: Arthritis Foundation Postdoctoral Fellowship Award; Nelson: NIH/NIAMS K23 AR061406. I. Aslam, BS, medical student, Northeast Ohio Medical School; I. Perjar, BA, medical student, University of North Carolina at Chapel Hill School of Medicine; X.A. Shi, PhD, staff statistician, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, and SAS Institute; J.B. Renner, MD, Professor, Department of Radiology, Thurston Arthritis Research Center and Department of Radiology, University of North Carolina at Chapel Hill; V.B. Kraus, MD, PhD, Professor of Medicine and Pathology, Associate Professor in Surgery, Duke University School of Medicine; Y.M. Golightly, PT, PhD, Assistant Professor of Epidemiology, Thurston Arthritis Research Center, and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill; J.M. Jordan, MD, MPH, Professor of Medicine and Orthopedics, Adjunct Professor of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Department of Epidemiology, Gillings School of Global Public Health, Department of Orthopedics, University of North Carolina at Chapel Hill; A.E. Nelson, MD, MSCR, Assistant Professor of Medicine, School of Medicine, and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill. Address correspondence to Dr. A.E. Nelson, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, CB #7280, Chapel Hill, North Carolina 27599-7280, USA. E-mail: aenelson@med.unc.edu. Accepted for publication November 19, 2013.
Jordan B. Renner
From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA. Funded in part by: Aslam/Perjar: American Geriatrics Society Medical Student Training in Aging Research (MSTAR) program; Perjar: American College of Rheumatology/Rheumatology Research Foundation Medical Student Research Preceptorship; Kraus: US National Institutes of Health (NIH)/National Institute on Aging Claude D. Pepper Older American Independence Centers P60 AG11268 and P30 AG028716, NIH/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) U01 AR050898; Jordan/Renner: US Centers for Disease Control and Prevention/Association of Schools of Public Health S043 and S3486, NIH/NIAMS Multidisciplinary Clinical Research Centers P60 AR49465; Golightly: Arthritis Foundation Postdoctoral Fellowship Award; Nelson: NIH/NIAMS K23 AR061406. I. Aslam, BS, medical student, Northeast Ohio Medical School; I. Perjar, BA, medical student, University of North Carolina at Chapel Hill School of Medicine; X.A. Shi, PhD, staff statistician, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, and SAS Institute; J.B. Renner, MD, Professor, Department of Radiology, Thurston Arthritis Research Center and Department of Radiology, University of North Carolina at Chapel Hill; V.B. Kraus, MD, PhD, Professor of Medicine and Pathology, Associate Professor in Surgery, Duke University School of Medicine; Y.M. Golightly, PT, PhD, Assistant Professor of Epidemiology, Thurston Arthritis Research Center, and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill; J.M. Jordan, MD, MPH, Professor of Medicine and Orthopedics, Adjunct Professor of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Department of Epidemiology, Gillings School of Global Public Health, Department of Orthopedics, University of North Carolina at Chapel Hill; A.E. Nelson, MD, MSCR, Assistant Professor of Medicine, School of Medicine, and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill. Address correspondence to Dr. A.E. Nelson, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, CB #7280, Chapel Hill, North Carolina 27599-7280, USA. E-mail: aenelson@med.unc.edu. Accepted for publication November 19, 2013.
Virginia B. Kraus
From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA. Funded in part by: Aslam/Perjar: American Geriatrics Society Medical Student Training in Aging Research (MSTAR) program; Perjar: American College of Rheumatology/Rheumatology Research Foundation Medical Student Research Preceptorship; Kraus: US National Institutes of Health (NIH)/National Institute on Aging Claude D. Pepper Older American Independence Centers P60 AG11268 and P30 AG028716, NIH/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) U01 AR050898; Jordan/Renner: US Centers for Disease Control and Prevention/Association of Schools of Public Health S043 and S3486, NIH/NIAMS Multidisciplinary Clinical Research Centers P60 AR49465; Golightly: Arthritis Foundation Postdoctoral Fellowship Award; Nelson: NIH/NIAMS K23 AR061406. I. Aslam, BS, medical student, Northeast Ohio Medical School; I. Perjar, BA, medical student, University of North Carolina at Chapel Hill School of Medicine; X.A. Shi, PhD, staff statistician, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, and SAS Institute; J.B. Renner, MD, Professor, Department of Radiology, Thurston Arthritis Research Center and Department of Radiology, University of North Carolina at Chapel Hill; V.B. Kraus, MD, PhD, Professor of Medicine and Pathology, Associate Professor in Surgery, Duke University School of Medicine; Y.M. Golightly, PT, PhD, Assistant Professor of Epidemiology, Thurston Arthritis Research Center, and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill; J.M. Jordan, MD, MPH, Professor of Medicine and Orthopedics, Adjunct Professor of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Department of Epidemiology, Gillings School of Global Public Health, Department of Orthopedics, University of North Carolina at Chapel Hill; A.E. Nelson, MD, MSCR, Assistant Professor of Medicine, School of Medicine, and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill. Address correspondence to Dr. A.E. Nelson, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, CB #7280, Chapel Hill, North Carolina 27599-7280, USA. E-mail: aenelson@med.unc.edu. Accepted for publication November 19, 2013.
Yvonne M. Golightly
From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA. Funded in part by: Aslam/Perjar: American Geriatrics Society Medical Student Training in Aging Research (MSTAR) program; Perjar: American College of Rheumatology/Rheumatology Research Foundation Medical Student Research Preceptorship; Kraus: US National Institutes of Health (NIH)/National Institute on Aging Claude D. Pepper Older American Independence Centers P60 AG11268 and P30 AG028716, NIH/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) U01 AR050898; Jordan/Renner: US Centers for Disease Control and Prevention/Association of Schools of Public Health S043 and S3486, NIH/NIAMS Multidisciplinary Clinical Research Centers P60 AR49465; Golightly: Arthritis Foundation Postdoctoral Fellowship Award; Nelson: NIH/NIAMS K23 AR061406. I. Aslam, BS, medical student, Northeast Ohio Medical School; I. Perjar, BA, medical student, University of North Carolina at Chapel Hill School of Medicine; X.A. Shi, PhD, staff statistician, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, and SAS Institute; J.B. Renner, MD, Professor, Department of Radiology, Thurston Arthritis Research Center and Department of Radiology, University of North Carolina at Chapel Hill; V.B. Kraus, MD, PhD, Professor of Medicine and Pathology, Associate Professor in Surgery, Duke University School of Medicine; Y.M. Golightly, PT, PhD, Assistant Professor of Epidemiology, Thurston Arthritis Research Center, and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill; J.M. Jordan, MD, MPH, Professor of Medicine and Orthopedics, Adjunct Professor of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Department of Epidemiology, Gillings School of Global Public Health, Department of Orthopedics, University of North Carolina at Chapel Hill; A.E. Nelson, MD, MSCR, Assistant Professor of Medicine, School of Medicine, and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill. Address correspondence to Dr. A.E. Nelson, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, CB #7280, Chapel Hill, North Carolina 27599-7280, USA. E-mail: aenelson@med.unc.edu. Accepted for publication November 19, 2013.
Joanne M. Jordan
From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA. Funded in part by: Aslam/Perjar: American Geriatrics Society Medical Student Training in Aging Research (MSTAR) program; Perjar: American College of Rheumatology/Rheumatology Research Foundation Medical Student Research Preceptorship; Kraus: US National Institutes of Health (NIH)/National Institute on Aging Claude D. Pepper Older American Independence Centers P60 AG11268 and P30 AG028716, NIH/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) U01 AR050898; Jordan/Renner: US Centers for Disease Control and Prevention/Association of Schools of Public Health S043 and S3486, NIH/NIAMS Multidisciplinary Clinical Research Centers P60 AR49465; Golightly: Arthritis Foundation Postdoctoral Fellowship Award; Nelson: NIH/NIAMS K23 AR061406. I. Aslam, BS, medical student, Northeast Ohio Medical School; I. Perjar, BA, medical student, University of North Carolina at Chapel Hill School of Medicine; X.A. Shi, PhD, staff statistician, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, and SAS Institute; J.B. Renner, MD, Professor, Department of Radiology, Thurston Arthritis Research Center and Department of Radiology, University of North Carolina at Chapel Hill; V.B. Kraus, MD, PhD, Professor of Medicine and Pathology, Associate Professor in Surgery, Duke University School of Medicine; Y.M. Golightly, PT, PhD, Assistant Professor of Epidemiology, Thurston Arthritis Research Center, and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill; J.M. Jordan, MD, MPH, Professor of Medicine and Orthopedics, Adjunct Professor of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Department of Epidemiology, Gillings School of Global Public Health, Department of Orthopedics, University of North Carolina at Chapel Hill; A.E. Nelson, MD, MSCR, Assistant Professor of Medicine, School of Medicine, and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill. Address correspondence to Dr. A.E. Nelson, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, CB #7280, Chapel Hill, North Carolina 27599-7280, USA. E-mail: aenelson@med.unc.edu. Accepted for publication November 19, 2013.
Amanda E. Nelson
From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA. Funded in part by: Aslam/Perjar: American Geriatrics Society Medical Student Training in Aging Research (MSTAR) program; Perjar: American College of Rheumatology/Rheumatology Research Foundation Medical Student Research Preceptorship; Kraus: US National Institutes of Health (NIH)/National Institute on Aging Claude D. Pepper Older American Independence Centers P60 AG11268 and P30 AG028716, NIH/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) U01 AR050898; Jordan/Renner: US Centers for Disease Control and Prevention/Association of Schools of Public Health S043 and S3486, NIH/NIAMS Multidisciplinary Clinical Research Centers P60 AR49465; Golightly: Arthritis Foundation Postdoctoral Fellowship Award; Nelson: NIH/NIAMS K23 AR061406. I. Aslam, BS, medical student, Northeast Ohio Medical School; I. Perjar, BA, medical student, University of North Carolina at Chapel Hill School of Medicine; X.A. Shi, PhD, staff statistician, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, and SAS Institute; J.B. Renner, MD, Professor, Department of Radiology, Thurston Arthritis Research Center and Department of Radiology, University of North Carolina at Chapel Hill; V.B. Kraus, MD, PhD, Professor of Medicine and Pathology, Associate Professor in Surgery, Duke University School of Medicine; Y.M. Golightly, PT, PhD, Assistant Professor of Epidemiology, Thurston Arthritis Research Center, and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill; J.M. Jordan, MD, MPH, Professor of Medicine and Orthopedics, Adjunct Professor of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Department of Epidemiology, Gillings School of Global Public Health, Department of Orthopedics, University of North Carolina at Chapel Hill; A.E. Nelson, MD, MSCR, Assistant Professor of Medicine, School of Medicine, and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill. Address correspondence to Dr. A.E. Nelson, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, CB #7280, Chapel Hill, North Carolina 27599-7280, USA. E-mail: aenelson@med.unc.edu. Accepted for publication November 19, 2013.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Associations Between Biomarkers of Joint Metabolism, Hand Osteoarthritis, and Hand Pain and Function: The Johnston County Osteoarthritis Project
Imran Aslam, Irina Perjar, Xiaoyan A. Shi, Jordan B. Renner, Virginia B. Kraus, Yvonne M. Golightly, Joanne M. Jordan, Amanda E. Nelson
The Journal of Rheumatology Mar 2014, jrheum.130904; DOI: 10.3899/jrheum.130904
Associations Between Biomarkers of Joint Metabolism, Hand Osteoarthritis, and Hand Pain and Function: The Johnston County Osteoarthritis Project
Imran Aslam, Irina Perjar, Xiaoyan A. Shi, Jordan B. Renner, Virginia B. Kraus, Yvonne M. Golightly, Joanne M. Jordan, Amanda E. Nelson
The Journal of Rheumatology Mar 2014, jrheum.130904; DOI: 10.3899/jrheum.130904