Research ArticleArticle
Independent Relationship of Osteoprotegerin Concentrations with Endothelial Activation and Carotid Atherosclerosis in Patients with Severe Rheumatoid Arthritis
Patrick H. Dessein, Raquel López-Mejias, Carlos González-Juanatey, Fernanda Genre, José A. Miranda-Filloy, Javier Llorca and Miguel A. González-Gay
The Journal of Rheumatology February 2014, jrheum.131037; DOI: https://doi.org/10.3899/jrheum.131037
Patrick H. Dessein
From the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander; Cardiology Division, Hospital Xeral-Calde, Lugo; Rheumatology Division, Hospital Xeral-Calde, Lugo; Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain. Supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 (Spain). This work was also partially supported by RETICS Program, RD08/0075 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII; Spain), and a Medical Research Council Grant (MRC2008_DES) from the National Research Foundation (South Africa; PH Dessein). Drs. Dessein and Gonzalez-Gay share senior authorship. P.H. Dessein, MD, FCP(SA), FRCP(UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; R. López-Mejias, PhD; F. Genre, PhD; M.A. González-Gay, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV; C. González-Juanatey, MD, PhD, Cardiology Division, Hospital Xeral-Calde; J.A. Miranda-Filloy, MD, Rheumatology Division, Hospital Xeral-Calde; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBERESP. Address correspondence to Dr. P.H. Dessein, P.O. Box 1012, Melville 2109, Johannesburg, South Africa. E-mail: dessein@telkomsa.net. Accepted for publication November 8, 2013.
Raquel López-Mejias
From the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander; Cardiology Division, Hospital Xeral-Calde, Lugo; Rheumatology Division, Hospital Xeral-Calde, Lugo; Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain. Supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 (Spain). This work was also partially supported by RETICS Program, RD08/0075 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII; Spain), and a Medical Research Council Grant (MRC2008_DES) from the National Research Foundation (South Africa; PH Dessein). Drs. Dessein and Gonzalez-Gay share senior authorship. P.H. Dessein, MD, FCP(SA), FRCP(UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; R. López-Mejias, PhD; F. Genre, PhD; M.A. González-Gay, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV; C. González-Juanatey, MD, PhD, Cardiology Division, Hospital Xeral-Calde; J.A. Miranda-Filloy, MD, Rheumatology Division, Hospital Xeral-Calde; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBERESP. Address correspondence to Dr. P.H. Dessein, P.O. Box 1012, Melville 2109, Johannesburg, South Africa. E-mail: dessein@telkomsa.net. Accepted for publication November 8, 2013.
Carlos González-Juanatey
From the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander; Cardiology Division, Hospital Xeral-Calde, Lugo; Rheumatology Division, Hospital Xeral-Calde, Lugo; Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain. Supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 (Spain). This work was also partially supported by RETICS Program, RD08/0075 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII; Spain), and a Medical Research Council Grant (MRC2008_DES) from the National Research Foundation (South Africa; PH Dessein). Drs. Dessein and Gonzalez-Gay share senior authorship. P.H. Dessein, MD, FCP(SA), FRCP(UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; R. López-Mejias, PhD; F. Genre, PhD; M.A. González-Gay, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV; C. González-Juanatey, MD, PhD, Cardiology Division, Hospital Xeral-Calde; J.A. Miranda-Filloy, MD, Rheumatology Division, Hospital Xeral-Calde; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBERESP. Address correspondence to Dr. P.H. Dessein, P.O. Box 1012, Melville 2109, Johannesburg, South Africa. E-mail: dessein@telkomsa.net. Accepted for publication November 8, 2013.
Fernanda Genre
From the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander; Cardiology Division, Hospital Xeral-Calde, Lugo; Rheumatology Division, Hospital Xeral-Calde, Lugo; Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain. Supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 (Spain). This work was also partially supported by RETICS Program, RD08/0075 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII; Spain), and a Medical Research Council Grant (MRC2008_DES) from the National Research Foundation (South Africa; PH Dessein). Drs. Dessein and Gonzalez-Gay share senior authorship. P.H. Dessein, MD, FCP(SA), FRCP(UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; R. López-Mejias, PhD; F. Genre, PhD; M.A. González-Gay, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV; C. González-Juanatey, MD, PhD, Cardiology Division, Hospital Xeral-Calde; J.A. Miranda-Filloy, MD, Rheumatology Division, Hospital Xeral-Calde; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBERESP. Address correspondence to Dr. P.H. Dessein, P.O. Box 1012, Melville 2109, Johannesburg, South Africa. E-mail: dessein@telkomsa.net. Accepted for publication November 8, 2013.
José A. Miranda-Filloy
From the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander; Cardiology Division, Hospital Xeral-Calde, Lugo; Rheumatology Division, Hospital Xeral-Calde, Lugo; Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain. Supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 (Spain). This work was also partially supported by RETICS Program, RD08/0075 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII; Spain), and a Medical Research Council Grant (MRC2008_DES) from the National Research Foundation (South Africa; PH Dessein). Drs. Dessein and Gonzalez-Gay share senior authorship. P.H. Dessein, MD, FCP(SA), FRCP(UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; R. López-Mejias, PhD; F. Genre, PhD; M.A. González-Gay, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV; C. González-Juanatey, MD, PhD, Cardiology Division, Hospital Xeral-Calde; J.A. Miranda-Filloy, MD, Rheumatology Division, Hospital Xeral-Calde; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBERESP. Address correspondence to Dr. P.H. Dessein, P.O. Box 1012, Melville 2109, Johannesburg, South Africa. E-mail: dessein@telkomsa.net. Accepted for publication November 8, 2013.
Javier Llorca
From the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander; Cardiology Division, Hospital Xeral-Calde, Lugo; Rheumatology Division, Hospital Xeral-Calde, Lugo; Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain. Supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 (Spain). This work was also partially supported by RETICS Program, RD08/0075 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII; Spain), and a Medical Research Council Grant (MRC2008_DES) from the National Research Foundation (South Africa; PH Dessein). Drs. Dessein and Gonzalez-Gay share senior authorship. P.H. Dessein, MD, FCP(SA), FRCP(UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; R. López-Mejias, PhD; F. Genre, PhD; M.A. González-Gay, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV; C. González-Juanatey, MD, PhD, Cardiology Division, Hospital Xeral-Calde; J.A. Miranda-Filloy, MD, Rheumatology Division, Hospital Xeral-Calde; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBERESP. Address correspondence to Dr. P.H. Dessein, P.O. Box 1012, Melville 2109, Johannesburg, South Africa. E-mail: dessein@telkomsa.net. Accepted for publication November 8, 2013.
Miguel A. González-Gay
From the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander; Cardiology Division, Hospital Xeral-Calde, Lugo; Rheumatology Division, Hospital Xeral-Calde, Lugo; Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain. Supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 (Spain). This work was also partially supported by RETICS Program, RD08/0075 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII; Spain), and a Medical Research Council Grant (MRC2008_DES) from the National Research Foundation (South Africa; PH Dessein). Drs. Dessein and Gonzalez-Gay share senior authorship. P.H. Dessein, MD, FCP(SA), FRCP(UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; R. López-Mejias, PhD; F. Genre, PhD; M.A. González-Gay, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV; C. González-Juanatey, MD, PhD, Cardiology Division, Hospital Xeral-Calde; J.A. Miranda-Filloy, MD, Rheumatology Division, Hospital Xeral-Calde; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBERESP. Address correspondence to Dr. P.H. Dessein, P.O. Box 1012, Melville 2109, Johannesburg, South Africa. E-mail: dessein@telkomsa.net. Accepted for publication November 8, 2013.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Independent Relationship of Osteoprotegerin Concentrations with Endothelial Activation and Carotid Atherosclerosis in Patients with Severe Rheumatoid Arthritis
Patrick H. Dessein, Raquel López-Mejias, Carlos González-Juanatey, Fernanda Genre, José A. Miranda-Filloy, Javier Llorca, Miguel A. González-Gay
The Journal of Rheumatology Feb 2014, jrheum.131037; DOI: 10.3899/jrheum.131037
Independent Relationship of Osteoprotegerin Concentrations with Endothelial Activation and Carotid Atherosclerosis in Patients with Severe Rheumatoid Arthritis
Patrick H. Dessein, Raquel López-Mejias, Carlos González-Juanatey, Fernanda Genre, José A. Miranda-Filloy, Javier Llorca, Miguel A. González-Gay
The Journal of Rheumatology Feb 2014, jrheum.131037; DOI: 10.3899/jrheum.131037