Research ArticleArticle
Antihomocitrullinated Fibrinogen Antibodies are Specific to Rheumatoid Arthritis and Frequently Bind Citrullinated Proteins/peptides
Mathias Scinocca, David A. Bell, Maud Racapé, Radha Joseph, Gary Shaw, John K. McCormick, Dafna D. Gladman, Janet Pope, Lillian Barra and Ewa Cairns
The Journal of Rheumatology January 2014, jrheum.130742; DOI: https://doi.org/10.3899/jrheum.130742
Mathias Scinocca
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
David A. Bell
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
Maud Racapé
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
Radha Joseph
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
Gary Shaw
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
John K. McCormick
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
Dafna D. Gladman
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
Janet Pope
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
Lillian Barra
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
Ewa Cairns
From the Department of Microbiology and Immunology, the Department of Medicine/Rheumatology, the Department of Biochemistry, and the Centre for Human Immunology, Western University, London, Ontario; and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada. Supported by grants from The Canadian Institutes of Health Research (102817) and The Arthritis Society (RG10/010) to Drs. Cairns and Bell. Dr. Cairns is supported by an award from The Calder Foundation. M. Scinocca has been supported by a graduate studentship award from The Ontario Ministry of Training, Colleges and Universities, and by the Canadian Institutes of Health Research. M. Scinocca, MSc, Department of Microbiology and Immunology, Western University; D.A. Bell, MD, Department of Medicine/Rheumatology; M. Racapé, PhD, Department of Microbiology and Immunology; R. Joseph, BMSc, Department of Medicine/Rheumatology; G. Shaw, PhD, Department of Biochemistry; J.K. McCormick, PhD, Centre for Human Immunology, Department of Microbiology and Immunology, Western University; D.D. Gladman, MD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; J.E. Pope, MD, MPH; L. Barra, MD, Department of Medicine/Rheumatology; E. Cairns, PhD, Department of Microbiology and Immunology, Western University, Department of Medicine/Rheumatology, the Centre for Human Immunology. Address correspondence to E. Cairns, Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building, Room 3014, London, Ontario N6A 5C1, Canada. E-mail: ewa.cairns@schulich.uwo.ca. Accepted for publication October 25, 2013.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Antihomocitrullinated Fibrinogen Antibodies are Specific to Rheumatoid Arthritis and Frequently Bind Citrullinated Proteins/peptides
Mathias Scinocca, David A. Bell, Maud Racapé, Radha Joseph, Gary Shaw, John K. McCormick, Dafna D. Gladman, Janet Pope, Lillian Barra, Ewa Cairns
The Journal of Rheumatology Jan 2014, jrheum.130742; DOI: 10.3899/jrheum.130742
Antihomocitrullinated Fibrinogen Antibodies are Specific to Rheumatoid Arthritis and Frequently Bind Citrullinated Proteins/peptides
Mathias Scinocca, David A. Bell, Maud Racapé, Radha Joseph, Gary Shaw, John K. McCormick, Dafna D. Gladman, Janet Pope, Lillian Barra, Ewa Cairns
The Journal of Rheumatology Jan 2014, jrheum.130742; DOI: 10.3899/jrheum.130742