Research ArticleArticle
Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study
Ali Guermazi, Daichi Hayashi, Frank W. Roemer, Yanyan Zhu, Jingbo Niu, Michel D. Crema, M. Kassim Javaid, Monica D. Marra, John A. Lynch, George Y. El-Khoury, Yuqing Zhang, Michael C. Nevitt and David T. Felson
The Journal of Rheumatology January 2014, jrheum.130541; DOI: https://doi.org/10.3899/jrheum.130541
Ali Guermazi
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
Daichi Hayashi
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
Frank W. Roemer
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
Yanyan Zhu
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
Jingbo Niu
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
Michel D. Crema
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
M. Kassim Javaid
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
Monica D. Marra
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
John A. Lynch
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
George Y. El-Khoury
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
Yuqing Zhang
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
Michael C. Nevitt
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
David T. Felson
From the Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA; Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, USA; Department of Radiology, University of Erlangen, Erlangen, Germany; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, Brazil; Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Radiology at the University of Iowa, Iowa City, IA, USA. Supported by National Institutes of Health (NIH) grants from the National Institute on Aging (U01-AG-18947, U01-AG-18832, U01-AG-19069, and U01-AG-18820). The MOST ancillary study is supported by NIH grants R01-AR053161 and K23AR053855. Dr. Guermazi is the president of Boston Imaging Core Lab LLC (BICL), Boston, Massachusetts, USA, a company providing radiological image assessment services. He is a consultant to MerckSerono, Sanofi-Aventis, and TissueGene. Drs. Roemer, Crema, and Marra are shareholders of BICL. Dr. Roemer is a consultant to MerckSerono and the NIH. A. Guermazi, MD, PhD, Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine; D. Hayashi, MD, PhD, Research Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, Bridgeport Hospital, Yale University School of Medicine; F.W. Roemer, MD, Associate Professor of Radiology, Department of Radiology, Boston University School of Medicine, and Department of Radiology, University of Erlangen; Y. Zhu, PhD, Research Assistant Professor; J. Niu, DSc, Research Assistant Professor, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.D. Crema, MD, Adjunct Assistant Professor of Radiology, QIC, Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem; M.K. Javaid, MBBS, PhD, Norman Collisson Senior Research Fellow and Lecturer in Metabolic Bone Disease, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; M.D. Marra, MD, Research Instructor, QIC, Department of Radiology, Boston University School of Medicine; J.A. Lynch, PhD, Director, MRI Quality Assurance, Department of Epidemiology and Biostatistics, University of California San Francisco; G.Y. El-Khoury, MD, Professor, Department of Radiology at the University of Iowa; Y. Zhang, ScD, Professor of Medicine and Public Health, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Division of Clinical Trials and Multicenter Studies, Department of Epidemiology and Biostatistics, University of California San Francisco; D.T. Felson, MD, MPH, Professor of Medicine and Epidemiology, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address correspondence to Dr. A. Guermazi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. E-mail: guermazi@bu.edu. Accepted for publication November 29, 2013.
Published eLetters
eLetters are comments published online only and are not peer-reviewed. Publication of eLetter submissions is not guaranteed, and all submissions are reviewed and edited at the discretion of The Journal's staff.
If you wish to publish Letters to the Editor or Correspondence, please submit through our online submission system ScholarOne Manuscripts.
Jump to comment:
No eLetters have been published for this article.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study
Ali Guermazi, Daichi Hayashi, Frank W. Roemer, Yanyan Zhu, Jingbo Niu, Michel D. Crema, M. Kassim Javaid, Monica D. Marra, John A. Lynch, George Y. El-Khoury, Yuqing Zhang, Michael C. Nevitt, David T. Felson
The Journal of Rheumatology Jan 2014, jrheum.130541; DOI: 10.3899/jrheum.130541
Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study
Ali Guermazi, Daichi Hayashi, Frank W. Roemer, Yanyan Zhu, Jingbo Niu, Michel D. Crema, M. Kassim Javaid, Monica D. Marra, John A. Lynch, George Y. El-Khoury, Yuqing Zhang, Michael C. Nevitt, David T. Felson
The Journal of Rheumatology Jan 2014, jrheum.130541; DOI: 10.3899/jrheum.130541