Research ArticleArticle
The Effects of Monosodium Urate Monohydrate Crystals on Chondrocyte Viability and Function: Implications for Development of Cartilage Damage in Gout
Ashika Chhana, Karen E. Callon, Bregina Pool, Dorit Naot, Gregory D. Gamble, Michael Dray, Rocco Pitto, Jarome Bentley, Fiona M. McQueen, Jillian Cornish and Nicola Dalbeth
The Journal of Rheumatology November 2013, jrheum.130708; DOI: https://doi.org/10.3899/jrheum.130708
Ashika Chhana
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Karen E. Callon
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Bregina Pool
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Dorit Naot
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Gregory D. Gamble
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Michael Dray
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Rocco Pitto
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Jarome Bentley
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Fiona M. McQueen
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Jillian Cornish
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
Nicola Dalbeth
From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland; and the Department of Histology, Waikato Hospital, Hamilton, New Zealand. Supported by a University of Auckland Doctoral Scholarship (AC) and the Auckland Medical Research Foundation. A. Chhana, BSc (Hons); K.E. Callon, BSc; B. Pool, BSc (Hons); D. Naot, PhD; G.D. Gamble, MSc; F.M. McQueen, MD, FRACP; J. Cornish, PhD; N. Dalbeth, MD, FRACP, Bone and Joint Research Group, Department of Medicine, University of Auckland; M. Dray, MB, ChB, FRCPA, Department of Histology, Waikato Hospital; R. Pitto, MD, PhD, FRACS; J. Bentley, MB, ChB, Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland. Address correspondence to Dr. N. Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. E-mail: n.dalbeth@auckland.ac.nz. Accepted for publication August 29, 2013.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
The Effects of Monosodium Urate Monohydrate Crystals on Chondrocyte Viability and Function: Implications for Development of Cartilage Damage in Gout
Ashika Chhana, Karen E. Callon, Bregina Pool, Dorit Naot, Gregory D. Gamble, Michael Dray, Rocco Pitto, Jarome Bentley, Fiona M. McQueen, Jillian Cornish, Nicola Dalbeth
The Journal of Rheumatology Nov 2013, jrheum.130708; DOI: 10.3899/jrheum.130708
The Effects of Monosodium Urate Monohydrate Crystals on Chondrocyte Viability and Function: Implications for Development of Cartilage Damage in Gout
Ashika Chhana, Karen E. Callon, Bregina Pool, Dorit Naot, Gregory D. Gamble, Michael Dray, Rocco Pitto, Jarome Bentley, Fiona M. McQueen, Jillian Cornish, Nicola Dalbeth
The Journal of Rheumatology Nov 2013, jrheum.130708; DOI: 10.3899/jrheum.130708