Research ArticleArticle
Familial Mediterranean Fever (FMF) with Proteinuria: Clinical Features, Histology, Predictors, and Prognosis in a Cohort of 25 Patients
Olga Kukuy, Avi Livneh, Aharon Ben-David, Juri Kopolovic, Alexander Volkov, Yael Shinar, Eliezer Holtzman, Dganit Dinour and Ilan Ben-Zvi
The Journal of Rheumatology October 2013, jrheum.130520; DOI: https://doi.org/10.3899/jrheum.130520
Olga Kukuy
From the Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer; Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer; Department of Pathology, Sheba Medical Center, Tel Hashomer; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center, Tel Hashomer, Israel. Drs. Kukuy and Livneh contributed equally to this work. O. Kukuy, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; A. Livneh, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University; A. Ben-David, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; J. Kopolovic, MD, Department of Pathology, Hadassah-Hebrew University Medical Center; A. Volkov, MD, Department of Pathology, Sheba Medical Center; Y. Shinar, PhD, Heller Institute of Medical Research, Sheba Medical Center; E. Holtzman, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; D. Dinour, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; and I. Ben-Zvi, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, and The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center. Address correspondence to Dr. Ilan Ben-Zvi. Department of Medicine F and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Tel: +97 25 44 89 6620. Fax: +97 23 530 8044. Email: Ilan.Benzvi@sheba.health.gov.il Accepted August 8, 2013.
Avi Livneh
From the Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer; Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer; Department of Pathology, Sheba Medical Center, Tel Hashomer; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center, Tel Hashomer, Israel. Drs. Kukuy and Livneh contributed equally to this work. O. Kukuy, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; A. Livneh, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University; A. Ben-David, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; J. Kopolovic, MD, Department of Pathology, Hadassah-Hebrew University Medical Center; A. Volkov, MD, Department of Pathology, Sheba Medical Center; Y. Shinar, PhD, Heller Institute of Medical Research, Sheba Medical Center; E. Holtzman, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; D. Dinour, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; and I. Ben-Zvi, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, and The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center. Address correspondence to Dr. Ilan Ben-Zvi. Department of Medicine F and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Tel: +97 25 44 89 6620. Fax: +97 23 530 8044. Email: Ilan.Benzvi@sheba.health.gov.il Accepted August 8, 2013.
Aharon Ben-David
From the Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer; Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer; Department of Pathology, Sheba Medical Center, Tel Hashomer; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center, Tel Hashomer, Israel. Drs. Kukuy and Livneh contributed equally to this work. O. Kukuy, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; A. Livneh, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University; A. Ben-David, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; J. Kopolovic, MD, Department of Pathology, Hadassah-Hebrew University Medical Center; A. Volkov, MD, Department of Pathology, Sheba Medical Center; Y. Shinar, PhD, Heller Institute of Medical Research, Sheba Medical Center; E. Holtzman, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; D. Dinour, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; and I. Ben-Zvi, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, and The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center. Address correspondence to Dr. Ilan Ben-Zvi. Department of Medicine F and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Tel: +97 25 44 89 6620. Fax: +97 23 530 8044. Email: Ilan.Benzvi@sheba.health.gov.il Accepted August 8, 2013.
Juri Kopolovic
From the Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer; Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer; Department of Pathology, Sheba Medical Center, Tel Hashomer; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center, Tel Hashomer, Israel. Drs. Kukuy and Livneh contributed equally to this work. O. Kukuy, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; A. Livneh, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University; A. Ben-David, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; J. Kopolovic, MD, Department of Pathology, Hadassah-Hebrew University Medical Center; A. Volkov, MD, Department of Pathology, Sheba Medical Center; Y. Shinar, PhD, Heller Institute of Medical Research, Sheba Medical Center; E. Holtzman, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; D. Dinour, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; and I. Ben-Zvi, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, and The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center. Address correspondence to Dr. Ilan Ben-Zvi. Department of Medicine F and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Tel: +97 25 44 89 6620. Fax: +97 23 530 8044. Email: Ilan.Benzvi@sheba.health.gov.il Accepted August 8, 2013.
Alexander Volkov
From the Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer; Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer; Department of Pathology, Sheba Medical Center, Tel Hashomer; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center, Tel Hashomer, Israel. Drs. Kukuy and Livneh contributed equally to this work. O. Kukuy, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; A. Livneh, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University; A. Ben-David, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; J. Kopolovic, MD, Department of Pathology, Hadassah-Hebrew University Medical Center; A. Volkov, MD, Department of Pathology, Sheba Medical Center; Y. Shinar, PhD, Heller Institute of Medical Research, Sheba Medical Center; E. Holtzman, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; D. Dinour, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; and I. Ben-Zvi, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, and The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center. Address correspondence to Dr. Ilan Ben-Zvi. Department of Medicine F and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Tel: +97 25 44 89 6620. Fax: +97 23 530 8044. Email: Ilan.Benzvi@sheba.health.gov.il Accepted August 8, 2013.
Yael Shinar
From the Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer; Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer; Department of Pathology, Sheba Medical Center, Tel Hashomer; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center, Tel Hashomer, Israel. Drs. Kukuy and Livneh contributed equally to this work. O. Kukuy, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; A. Livneh, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University; A. Ben-David, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; J. Kopolovic, MD, Department of Pathology, Hadassah-Hebrew University Medical Center; A. Volkov, MD, Department of Pathology, Sheba Medical Center; Y. Shinar, PhD, Heller Institute of Medical Research, Sheba Medical Center; E. Holtzman, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; D. Dinour, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; and I. Ben-Zvi, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, and The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center. Address correspondence to Dr. Ilan Ben-Zvi. Department of Medicine F and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Tel: +97 25 44 89 6620. Fax: +97 23 530 8044. Email: Ilan.Benzvi@sheba.health.gov.il Accepted August 8, 2013.
Eliezer Holtzman
From the Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer; Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer; Department of Pathology, Sheba Medical Center, Tel Hashomer; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center, Tel Hashomer, Israel. Drs. Kukuy and Livneh contributed equally to this work. O. Kukuy, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; A. Livneh, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University; A. Ben-David, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; J. Kopolovic, MD, Department of Pathology, Hadassah-Hebrew University Medical Center; A. Volkov, MD, Department of Pathology, Sheba Medical Center; Y. Shinar, PhD, Heller Institute of Medical Research, Sheba Medical Center; E. Holtzman, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; D. Dinour, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; and I. Ben-Zvi, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, and The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center. Address correspondence to Dr. Ilan Ben-Zvi. Department of Medicine F and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Tel: +97 25 44 89 6620. Fax: +97 23 530 8044. Email: Ilan.Benzvi@sheba.health.gov.il Accepted August 8, 2013.
Dganit Dinour
From the Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer; Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer; Department of Pathology, Sheba Medical Center, Tel Hashomer; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center, Tel Hashomer, Israel. Drs. Kukuy and Livneh contributed equally to this work. O. Kukuy, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; A. Livneh, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University; A. Ben-David, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; J. Kopolovic, MD, Department of Pathology, Hadassah-Hebrew University Medical Center; A. Volkov, MD, Department of Pathology, Sheba Medical Center; Y. Shinar, PhD, Heller Institute of Medical Research, Sheba Medical Center; E. Holtzman, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; D. Dinour, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; and I. Ben-Zvi, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, and The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center. Address correspondence to Dr. Ilan Ben-Zvi. Department of Medicine F and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Tel: +97 25 44 89 6620. Fax: +97 23 530 8044. Email: Ilan.Benzvi@sheba.health.gov.il Accepted August 8, 2013.
Ilan Ben-Zvi
From the Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer; Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer; Department of Pathology, Sheba Medical Center, Tel Hashomer; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center, Tel Hashomer, Israel. Drs. Kukuy and Livneh contributed equally to this work. O. Kukuy, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; A. Livneh, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University; A. Ben-David, MD, Institute of Nephrology and Hypertension, Sheba Medical Center; J. Kopolovic, MD, Department of Pathology, Hadassah-Hebrew University Medical Center; A. Volkov, MD, Department of Pathology, Sheba Medical Center; Y. Shinar, PhD, Heller Institute of Medical Research, Sheba Medical Center; E. Holtzman, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; D. Dinour, MD, Institute of Nephrology and Hypertension, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University; and I. Ben-Zvi, MD, Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, and The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012, Chaim Sheba Medical Center. Address correspondence to Dr. Ilan Ben-Zvi. Department of Medicine F and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Tel: +97 25 44 89 6620. Fax: +97 23 530 8044. Email: Ilan.Benzvi@sheba.health.gov.il Accepted August 8, 2013.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Familial Mediterranean Fever (FMF) with Proteinuria: Clinical Features, Histology, Predictors, and Prognosis in a Cohort of 25 Patients
Olga Kukuy, Avi Livneh, Aharon Ben-David, Juri Kopolovic, Alexander Volkov, Yael Shinar, Eliezer Holtzman, Dganit Dinour, Ilan Ben-Zvi
The Journal of Rheumatology Oct 2013, jrheum.130520; DOI: 10.3899/jrheum.130520
Familial Mediterranean Fever (FMF) with Proteinuria: Clinical Features, Histology, Predictors, and Prognosis in a Cohort of 25 Patients
Olga Kukuy, Avi Livneh, Aharon Ben-David, Juri Kopolovic, Alexander Volkov, Yael Shinar, Eliezer Holtzman, Dganit Dinour, Ilan Ben-Zvi
The Journal of Rheumatology Oct 2013, jrheum.130520; DOI: 10.3899/jrheum.130520