Research ArticleArticle
Signal Hyperintensities on Brain Magnetic Resonance Imaging in Patients with Primary Sjögren Syndrome and Frequent Episodic Tension-type Headache: Relation to Platelet Serotonin Level and Disease Activity
Helena Šarac, Jasenka Markeljević, Viktorija Erdeljić, Zeljka Josipović-Jelić, Sanja Hajnšek, Tatjana Klapan, Marko Batinica, Ivana Baršić, Jadranka Sertić and Renata Dobrila Dintinjana
The Journal of Rheumatology June 2013, jrheum.121132; DOI: https://doi.org/10.3899/jrheum.121132
Helena Šarac
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
Jasenka Markeljević
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
Viktorija Erdeljić
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
Zeljka Josipović-Jelić
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
Sanja Hajnšek
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
Tatjana Klapan
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
Marko Batinica
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
Ivana Baršić
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
Jadranka Sertić
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
Renata Dobrila Dintinjana
From the Department of Neurology, University Hospital Zagreb; Croatian Institute for Brain Research, Medical School Zagreb; Medical School, University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Diagnostic Centre Medikol, Zagreb; Department of Laboratory Diagnostic, University Hospital Zagreb, Zagreb; and Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology, Rijeka, Croatia. Supported by the Croatian Ministry of Science, Education and Sport, Projects Sjögren’s Syndrome: Neurohumoral Regulation of Autoimmunity and Atherogenesis, No. 108-1081874-2416 and No. 098 098-1081870-2397. H. Šarac, MD, Department of Neurology, University Hospital Zagreb, Croatian Institute for Brain Research, Medical School Zagreb; J. Markeljevic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; V. Erdeljic, MD, PhD, Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb; Z. Josipovic-Jelic, MD, PhD, Diagnostic Centre Medikol; S. Hajnšek, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; T. Klapan, MD; M. Batinica, MD, Diagnostic Centre Medikol; I. Barsic, Biochemistry Ing., Department of Laboratory Diagnostic, University Hospital Zagreb; J. Sertic, MD, PhD, Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sisters of Mercy; R. Dobrila-Dintinjana, MD, PhD, Medical School University of Rijeka, University Hospital Rijeka, Department of Oncology. Address correspondence to Dr. H. Šarac, Department of Neurology, University Hospital Zagreb, Oboj 9b, 10 000 Zagreb, Croatia. E-mail: helenasarac@hi.t-com.hr. Accepted for publication April 4, 2013.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Signal Hyperintensities on Brain Magnetic Resonance Imaging in Patients with Primary Sjögren Syndrome and Frequent Episodic Tension-type Headache: Relation to Platelet Serotonin Level and Disease Activity
Helena Šarac, Jasenka Markeljević, Viktorija Erdeljić, Zeljka Josipović-Jelić, Sanja Hajnšek, Tatjana Klapan, Marko Batinica, Ivana Baršić, Jadranka Sertić, Renata Dobrila Dintinjana
The Journal of Rheumatology Jun 2013, jrheum.121132; DOI: 10.3899/jrheum.121132
Signal Hyperintensities on Brain Magnetic Resonance Imaging in Patients with Primary Sjögren Syndrome and Frequent Episodic Tension-type Headache: Relation to Platelet Serotonin Level and Disease Activity
Helena Šarac, Jasenka Markeljević, Viktorija Erdeljić, Zeljka Josipović-Jelić, Sanja Hajnšek, Tatjana Klapan, Marko Batinica, Ivana Baršić, Jadranka Sertić, Renata Dobrila Dintinjana
The Journal of Rheumatology Jun 2013, jrheum.121132; DOI: 10.3899/jrheum.121132