Research ArticleArticle
HLA-G 3' Untranslated Region Polymorphisms Are Associated with Systemic Lupus Erythematosus in 2 Brazilian Populations
Norma Lucena-Silva, Veridiana Sales Barbosa de Souza, Renan Garcia Gomes, Alex Fantinatti, Yara Costa Netto Muniz, Rafael Sales de Albuquerque, Alessandra Luna Ramos Monteiro, George Tadeu Nunes Diniz, Maria Rosângela Cunha Duarte Coelho, Celso Teixeira Mendes-Junior, Erick da Cruz Castelli and Eduardo Antônio Donadi
The Journal of Rheumatology May 2013, jrheum.120814; DOI: https://doi.org/10.3899/jrheum.120814
Norma Lucena-Silva
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Veridiana Sales Barbosa de Souza
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Renan Garcia Gomes
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Alex Fantinatti
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Yara Costa Netto Muniz
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Rafael Sales de Albuquerque
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Alessandra Luna Ramos Monteiro
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
George Tadeu Nunes Diniz
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Maria Rosângela Cunha Duarte Coelho
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Celso Teixeira Mendes-Junior
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Erick da Cruz Castelli
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
Eduardo Antônio Donadi
From the Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, Recife-PE; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP; Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife-PE; Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP; and Department of General Biology, Biological Science Institute, Federal University of Goias (UFG), Goiânia-GO, Brazil. The Program for Technological Development in Tools for Health-PDTISFIOCRUZ provided financial support for gene sequencing. R.G. Gomes is supported by FACEPE (APQ-0184-4.01/10) and Dr. Lucena-Silva is the recipient of a postdoctoral fellowship from CNPq (PDS 150572/2011-5). N. Lucena-Silva, PhD, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; V.S.B. de Souza, MSc, Virology Division, LIKA, UFPE; R.G. Gomes, Graduate in Biomedicine, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; A. Fantinatti, Graduate in Medicine; Y.C.N. Muniz, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; R.S. de Albuquerque, MSc, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, and Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo; A.L.R. Monteiro, Graduate in Biomedicine, Molecular Biology Laboratory, Department of Pediatric Oncology, IMIP Hospital; G.T.N. Diniz, Statistician, Laboratory of Quantitative Methods, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation; M.R.C.D. Coelho, PhD, Virology Division, LIKA, UFPE; C.T. Mendes-Junior, PhD, Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo; E.C. Castelli, PhD, Department of General Biology, Biological Science Institute, UFG; E.A. Donadi, PhD, Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo. Dr. Lucena-Silva, V.S.B. de Souza, Dr. Mendes-Junior, Dr. Castelli, and Dr. Donadi contributed equally to this article. Address correspondence to Dr. N. Lucena-Silva, Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Moraes Rego, s/n, Cidade Universitária, Recife, PE, Brazil, CEP 50720-640. E-mail: norma.lucena@hotmail.com Accepted for publication March 19, 2013.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
HLA-G 3' Untranslated Region Polymorphisms Are Associated with Systemic Lupus Erythematosus in 2 Brazilian Populations
Norma Lucena-Silva, Veridiana Sales Barbosa de Souza, Renan Garcia Gomes, Alex Fantinatti, Yara Costa Netto Muniz, Rafael Sales de Albuquerque, Alessandra Luna Ramos Monteiro, George Tadeu Nunes Diniz, Maria Rosângela Cunha Duarte Coelho, Celso Teixeira Mendes-Junior, Erick da Cruz Castelli, Eduardo Antônio Donadi
The Journal of Rheumatology May 2013, jrheum.120814; DOI: 10.3899/jrheum.120814
HLA-G 3' Untranslated Region Polymorphisms Are Associated with Systemic Lupus Erythematosus in 2 Brazilian Populations
Norma Lucena-Silva, Veridiana Sales Barbosa de Souza, Renan Garcia Gomes, Alex Fantinatti, Yara Costa Netto Muniz, Rafael Sales de Albuquerque, Alessandra Luna Ramos Monteiro, George Tadeu Nunes Diniz, Maria Rosângela Cunha Duarte Coelho, Celso Teixeira Mendes-Junior, Erick da Cruz Castelli, Eduardo Antônio Donadi
The Journal of Rheumatology May 2013, jrheum.120814; DOI: 10.3899/jrheum.120814