Research ArticleArticle
Soluble Biomarkers Associated with Response to Treatment with Tumor Necrosis Factor Inhibitors in Psoriatic Arthritis
Vinod Chandran, Hua Shen, Remy A. Pollock, Fawnda J. Pellett, Adele Carty, Richard J. Cook and Dafna D. Gladman
The Journal of Rheumatology May 2013, jrheum.121162; DOI: https://doi.org/10.3899/jrheum.121162
Vinod Chandran
From the Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto; and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada. Supported in part by a grant from The Arthritis Society, the Canadian Institutes of Health Research (CIHR) Institute of Musculoskeletal Health and Arthritis, and the Krembil Foundation. Dr. Chandran was supported by a CIHR Clinical Research Initiative Fellowship and by the Krembil Foundation. He has received research funds from Abbott Canada, and has also received honoraria from Abbott Canada, Amgen/Pfizer Canada, Janssen Canada, Merck Canada, and Bristol-Myers Squibb Canada. Dr. Cook is a Canada Research Chair in Statistical Methods for Health Research and is supported by the CIHR. Dr. Gladman has received research grants from Abbott Canada, Amgen Canada, and Janssen, and has served as consultant to Abbott, Amgen, BMS, Centocor, Janssen, Pfizer, and UCB. V. Chandran, MBBS, MD, DM, Assistant Professor of Medicine, Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; H. Shen, MMath, Department of Statistics and Actuarial Science, University of Waterloo; R.A. Pollock, MSc, Research Technologist; F.J. Pellett, BSc, Research Technologist; A. Carty, BA, Research Assistant, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto; R.J. Cook, PhD, Professor, Department of Statistics and Actuarial Science, University of Waterloo; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Senior Scientist, Toronto Western Research Institute, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital. Address correspondence to Dr. D.D. Gladman, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario M5T 2S8, Canada. E-mail: dafna.gladman@utoronto.ca Accepted for publication February 14, 2013.
Hua Shen
From the Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto; and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada. Supported in part by a grant from The Arthritis Society, the Canadian Institutes of Health Research (CIHR) Institute of Musculoskeletal Health and Arthritis, and the Krembil Foundation. Dr. Chandran was supported by a CIHR Clinical Research Initiative Fellowship and by the Krembil Foundation. He has received research funds from Abbott Canada, and has also received honoraria from Abbott Canada, Amgen/Pfizer Canada, Janssen Canada, Merck Canada, and Bristol-Myers Squibb Canada. Dr. Cook is a Canada Research Chair in Statistical Methods for Health Research and is supported by the CIHR. Dr. Gladman has received research grants from Abbott Canada, Amgen Canada, and Janssen, and has served as consultant to Abbott, Amgen, BMS, Centocor, Janssen, Pfizer, and UCB. V. Chandran, MBBS, MD, DM, Assistant Professor of Medicine, Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; H. Shen, MMath, Department of Statistics and Actuarial Science, University of Waterloo; R.A. Pollock, MSc, Research Technologist; F.J. Pellett, BSc, Research Technologist; A. Carty, BA, Research Assistant, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto; R.J. Cook, PhD, Professor, Department of Statistics and Actuarial Science, University of Waterloo; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Senior Scientist, Toronto Western Research Institute, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital. Address correspondence to Dr. D.D. Gladman, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario M5T 2S8, Canada. E-mail: dafna.gladman@utoronto.ca Accepted for publication February 14, 2013.
Remy A. Pollock
From the Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto; and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada. Supported in part by a grant from The Arthritis Society, the Canadian Institutes of Health Research (CIHR) Institute of Musculoskeletal Health and Arthritis, and the Krembil Foundation. Dr. Chandran was supported by a CIHR Clinical Research Initiative Fellowship and by the Krembil Foundation. He has received research funds from Abbott Canada, and has also received honoraria from Abbott Canada, Amgen/Pfizer Canada, Janssen Canada, Merck Canada, and Bristol-Myers Squibb Canada. Dr. Cook is a Canada Research Chair in Statistical Methods for Health Research and is supported by the CIHR. Dr. Gladman has received research grants from Abbott Canada, Amgen Canada, and Janssen, and has served as consultant to Abbott, Amgen, BMS, Centocor, Janssen, Pfizer, and UCB. V. Chandran, MBBS, MD, DM, Assistant Professor of Medicine, Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; H. Shen, MMath, Department of Statistics and Actuarial Science, University of Waterloo; R.A. Pollock, MSc, Research Technologist; F.J. Pellett, BSc, Research Technologist; A. Carty, BA, Research Assistant, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto; R.J. Cook, PhD, Professor, Department of Statistics and Actuarial Science, University of Waterloo; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Senior Scientist, Toronto Western Research Institute, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital. Address correspondence to Dr. D.D. Gladman, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario M5T 2S8, Canada. E-mail: dafna.gladman@utoronto.ca Accepted for publication February 14, 2013.
Fawnda J. Pellett
From the Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto; and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada. Supported in part by a grant from The Arthritis Society, the Canadian Institutes of Health Research (CIHR) Institute of Musculoskeletal Health and Arthritis, and the Krembil Foundation. Dr. Chandran was supported by a CIHR Clinical Research Initiative Fellowship and by the Krembil Foundation. He has received research funds from Abbott Canada, and has also received honoraria from Abbott Canada, Amgen/Pfizer Canada, Janssen Canada, Merck Canada, and Bristol-Myers Squibb Canada. Dr. Cook is a Canada Research Chair in Statistical Methods for Health Research and is supported by the CIHR. Dr. Gladman has received research grants from Abbott Canada, Amgen Canada, and Janssen, and has served as consultant to Abbott, Amgen, BMS, Centocor, Janssen, Pfizer, and UCB. V. Chandran, MBBS, MD, DM, Assistant Professor of Medicine, Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; H. Shen, MMath, Department of Statistics and Actuarial Science, University of Waterloo; R.A. Pollock, MSc, Research Technologist; F.J. Pellett, BSc, Research Technologist; A. Carty, BA, Research Assistant, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto; R.J. Cook, PhD, Professor, Department of Statistics and Actuarial Science, University of Waterloo; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Senior Scientist, Toronto Western Research Institute, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital. Address correspondence to Dr. D.D. Gladman, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario M5T 2S8, Canada. E-mail: dafna.gladman@utoronto.ca Accepted for publication February 14, 2013.
Adele Carty
From the Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto; and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada. Supported in part by a grant from The Arthritis Society, the Canadian Institutes of Health Research (CIHR) Institute of Musculoskeletal Health and Arthritis, and the Krembil Foundation. Dr. Chandran was supported by a CIHR Clinical Research Initiative Fellowship and by the Krembil Foundation. He has received research funds from Abbott Canada, and has also received honoraria from Abbott Canada, Amgen/Pfizer Canada, Janssen Canada, Merck Canada, and Bristol-Myers Squibb Canada. Dr. Cook is a Canada Research Chair in Statistical Methods for Health Research and is supported by the CIHR. Dr. Gladman has received research grants from Abbott Canada, Amgen Canada, and Janssen, and has served as consultant to Abbott, Amgen, BMS, Centocor, Janssen, Pfizer, and UCB. V. Chandran, MBBS, MD, DM, Assistant Professor of Medicine, Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; H. Shen, MMath, Department of Statistics and Actuarial Science, University of Waterloo; R.A. Pollock, MSc, Research Technologist; F.J. Pellett, BSc, Research Technologist; A. Carty, BA, Research Assistant, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto; R.J. Cook, PhD, Professor, Department of Statistics and Actuarial Science, University of Waterloo; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Senior Scientist, Toronto Western Research Institute, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital. Address correspondence to Dr. D.D. Gladman, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario M5T 2S8, Canada. E-mail: dafna.gladman@utoronto.ca Accepted for publication February 14, 2013.
Richard J. Cook
From the Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto; and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada. Supported in part by a grant from The Arthritis Society, the Canadian Institutes of Health Research (CIHR) Institute of Musculoskeletal Health and Arthritis, and the Krembil Foundation. Dr. Chandran was supported by a CIHR Clinical Research Initiative Fellowship and by the Krembil Foundation. He has received research funds from Abbott Canada, and has also received honoraria from Abbott Canada, Amgen/Pfizer Canada, Janssen Canada, Merck Canada, and Bristol-Myers Squibb Canada. Dr. Cook is a Canada Research Chair in Statistical Methods for Health Research and is supported by the CIHR. Dr. Gladman has received research grants from Abbott Canada, Amgen Canada, and Janssen, and has served as consultant to Abbott, Amgen, BMS, Centocor, Janssen, Pfizer, and UCB. V. Chandran, MBBS, MD, DM, Assistant Professor of Medicine, Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; H. Shen, MMath, Department of Statistics and Actuarial Science, University of Waterloo; R.A. Pollock, MSc, Research Technologist; F.J. Pellett, BSc, Research Technologist; A. Carty, BA, Research Assistant, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto; R.J. Cook, PhD, Professor, Department of Statistics and Actuarial Science, University of Waterloo; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Senior Scientist, Toronto Western Research Institute, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital. Address correspondence to Dr. D.D. Gladman, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario M5T 2S8, Canada. E-mail: dafna.gladman@utoronto.ca Accepted for publication February 14, 2013.
Dafna D. Gladman
From the Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto; and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada. Supported in part by a grant from The Arthritis Society, the Canadian Institutes of Health Research (CIHR) Institute of Musculoskeletal Health and Arthritis, and the Krembil Foundation. Dr. Chandran was supported by a CIHR Clinical Research Initiative Fellowship and by the Krembil Foundation. He has received research funds from Abbott Canada, and has also received honoraria from Abbott Canada, Amgen/Pfizer Canada, Janssen Canada, Merck Canada, and Bristol-Myers Squibb Canada. Dr. Cook is a Canada Research Chair in Statistical Methods for Health Research and is supported by the CIHR. Dr. Gladman has received research grants from Abbott Canada, Amgen Canada, and Janssen, and has served as consultant to Abbott, Amgen, BMS, Centocor, Janssen, Pfizer, and UCB. V. Chandran, MBBS, MD, DM, Assistant Professor of Medicine, Department of Medicine, Division of Rheumatology, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; H. Shen, MMath, Department of Statistics and Actuarial Science, University of Waterloo; R.A. Pollock, MSc, Research Technologist; F.J. Pellett, BSc, Research Technologist; A. Carty, BA, Research Assistant, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto; R.J. Cook, PhD, Professor, Department of Statistics and Actuarial Science, University of Waterloo; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Senior Scientist, Toronto Western Research Institute, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital. Address correspondence to Dr. D.D. Gladman, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario M5T 2S8, Canada. E-mail: dafna.gladman@utoronto.ca Accepted for publication February 14, 2013.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Soluble Biomarkers Associated with Response to Treatment with Tumor Necrosis Factor Inhibitors in Psoriatic Arthritis
Vinod Chandran, Hua Shen, Remy A. Pollock, Fawnda J. Pellett, Adele Carty, Richard J. Cook, Dafna D. Gladman
The Journal of Rheumatology May 2013, jrheum.121162; DOI: 10.3899/jrheum.121162
Soluble Biomarkers Associated with Response to Treatment with Tumor Necrosis Factor Inhibitors in Psoriatic Arthritis
Vinod Chandran, Hua Shen, Remy A. Pollock, Fawnda J. Pellett, Adele Carty, Richard J. Cook, Dafna D. Gladman
The Journal of Rheumatology May 2013, jrheum.121162; DOI: 10.3899/jrheum.121162