Research ArticleArticle
The Early Protective Effect of Hydroxychloroquine on the Risk of Cumulative Damage in Patients with Systemic Lupus Erythematosus
Pooneh S. Akhavan, Jiandong Su, Wendy Lou, Dafna D. Gladman, Murray B. Urowitz and Paul R. Fortin
The Journal of Rheumatology April 2013, jrheum.120572; DOI: https://doi.org/10.3899/jrheum.120572
Pooneh S. Akhavan
From the Division of Rheumatology, Department of Medicine, University of Toronto; Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; Dalla Lana School of Public Health, University of Toronto; Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario; and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval, Québec City, Québec, Canada. P.R. Fortin held the Distinguished Senior Investigator Award of the Arthritis Society and presently holds a Canada Research Chair in Systemic Autoimmune Rheumatic Diseases. Additional support was provided by the Arthritis Centre of Excellence, University of Toronto, and the Department of Medicine and Centre de recherche du centre hospitalier universitaire de Québec, Université Laval. CaNIOS is supported in part by Lupus Canada, Lupus Ontario, the Lupus Foundation of Ontario and BC Lupus as well as by the Toronto General and Western Hospital Foundation. Additional support was received from Bristol-Myers Squibb Canada Inc. The Centre for Prognostic Studies in Rheumatic Diseases University of Toronto Lupus Clinic is supported in part by The Smythe Foundation, Lupus Ontario, Dance for the Cure, Flare for Fashion, and the Lupus Foundation of Ontario. P.S. Akhavan, MD, Staff Rheumatologist, Division of Rheumatology, Department of Medicine, University of Toronto; J. Su, BSc, Research Analyst, Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; W. Lou, PhD, Professor of Biostatistics and Statistics, Canada Research Chair in Statistical Methods for Health Care, Dalla Lana School of Public Health, University of Toronto; D.D. Gladman, MD, FRCPC, Senior Scientist; M.B. Urowitz, MD, FRCPC, Senior Scientist, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto; P.R. Fortin, MD, MPH, FRCPC, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval. Address correspondence to Dr. P.R. Fortin, Centre de recherche du CHU de Québec, CHUL, Room S-763, 2705, boulevard Laurier, Québec City, QC G1V 4G2, Canada. E-mail: paul.fortin@crchuq.ulaval.ca Accepted for publication February 4, 2013.
Jiandong Su
From the Division of Rheumatology, Department of Medicine, University of Toronto; Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; Dalla Lana School of Public Health, University of Toronto; Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario; and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval, Québec City, Québec, Canada. P.R. Fortin held the Distinguished Senior Investigator Award of the Arthritis Society and presently holds a Canada Research Chair in Systemic Autoimmune Rheumatic Diseases. Additional support was provided by the Arthritis Centre of Excellence, University of Toronto, and the Department of Medicine and Centre de recherche du centre hospitalier universitaire de Québec, Université Laval. CaNIOS is supported in part by Lupus Canada, Lupus Ontario, the Lupus Foundation of Ontario and BC Lupus as well as by the Toronto General and Western Hospital Foundation. Additional support was received from Bristol-Myers Squibb Canada Inc. The Centre for Prognostic Studies in Rheumatic Diseases University of Toronto Lupus Clinic is supported in part by The Smythe Foundation, Lupus Ontario, Dance for the Cure, Flare for Fashion, and the Lupus Foundation of Ontario. P.S. Akhavan, MD, Staff Rheumatologist, Division of Rheumatology, Department of Medicine, University of Toronto; J. Su, BSc, Research Analyst, Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; W. Lou, PhD, Professor of Biostatistics and Statistics, Canada Research Chair in Statistical Methods for Health Care, Dalla Lana School of Public Health, University of Toronto; D.D. Gladman, MD, FRCPC, Senior Scientist; M.B. Urowitz, MD, FRCPC, Senior Scientist, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto; P.R. Fortin, MD, MPH, FRCPC, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval. Address correspondence to Dr. P.R. Fortin, Centre de recherche du CHU de Québec, CHUL, Room S-763, 2705, boulevard Laurier, Québec City, QC G1V 4G2, Canada. E-mail: paul.fortin@crchuq.ulaval.ca Accepted for publication February 4, 2013.
Wendy Lou
From the Division of Rheumatology, Department of Medicine, University of Toronto; Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; Dalla Lana School of Public Health, University of Toronto; Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario; and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval, Québec City, Québec, Canada. P.R. Fortin held the Distinguished Senior Investigator Award of the Arthritis Society and presently holds a Canada Research Chair in Systemic Autoimmune Rheumatic Diseases. Additional support was provided by the Arthritis Centre of Excellence, University of Toronto, and the Department of Medicine and Centre de recherche du centre hospitalier universitaire de Québec, Université Laval. CaNIOS is supported in part by Lupus Canada, Lupus Ontario, the Lupus Foundation of Ontario and BC Lupus as well as by the Toronto General and Western Hospital Foundation. Additional support was received from Bristol-Myers Squibb Canada Inc. The Centre for Prognostic Studies in Rheumatic Diseases University of Toronto Lupus Clinic is supported in part by The Smythe Foundation, Lupus Ontario, Dance for the Cure, Flare for Fashion, and the Lupus Foundation of Ontario. P.S. Akhavan, MD, Staff Rheumatologist, Division of Rheumatology, Department of Medicine, University of Toronto; J. Su, BSc, Research Analyst, Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; W. Lou, PhD, Professor of Biostatistics and Statistics, Canada Research Chair in Statistical Methods for Health Care, Dalla Lana School of Public Health, University of Toronto; D.D. Gladman, MD, FRCPC, Senior Scientist; M.B. Urowitz, MD, FRCPC, Senior Scientist, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto; P.R. Fortin, MD, MPH, FRCPC, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval. Address correspondence to Dr. P.R. Fortin, Centre de recherche du CHU de Québec, CHUL, Room S-763, 2705, boulevard Laurier, Québec City, QC G1V 4G2, Canada. E-mail: paul.fortin@crchuq.ulaval.ca Accepted for publication February 4, 2013.
Dafna D. Gladman
From the Division of Rheumatology, Department of Medicine, University of Toronto; Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; Dalla Lana School of Public Health, University of Toronto; Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario; and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval, Québec City, Québec, Canada. P.R. Fortin held the Distinguished Senior Investigator Award of the Arthritis Society and presently holds a Canada Research Chair in Systemic Autoimmune Rheumatic Diseases. Additional support was provided by the Arthritis Centre of Excellence, University of Toronto, and the Department of Medicine and Centre de recherche du centre hospitalier universitaire de Québec, Université Laval. CaNIOS is supported in part by Lupus Canada, Lupus Ontario, the Lupus Foundation of Ontario and BC Lupus as well as by the Toronto General and Western Hospital Foundation. Additional support was received from Bristol-Myers Squibb Canada Inc. The Centre for Prognostic Studies in Rheumatic Diseases University of Toronto Lupus Clinic is supported in part by The Smythe Foundation, Lupus Ontario, Dance for the Cure, Flare for Fashion, and the Lupus Foundation of Ontario. P.S. Akhavan, MD, Staff Rheumatologist, Division of Rheumatology, Department of Medicine, University of Toronto; J. Su, BSc, Research Analyst, Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; W. Lou, PhD, Professor of Biostatistics and Statistics, Canada Research Chair in Statistical Methods for Health Care, Dalla Lana School of Public Health, University of Toronto; D.D. Gladman, MD, FRCPC, Senior Scientist; M.B. Urowitz, MD, FRCPC, Senior Scientist, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto; P.R. Fortin, MD, MPH, FRCPC, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval. Address correspondence to Dr. P.R. Fortin, Centre de recherche du CHU de Québec, CHUL, Room S-763, 2705, boulevard Laurier, Québec City, QC G1V 4G2, Canada. E-mail: paul.fortin@crchuq.ulaval.ca Accepted for publication February 4, 2013.
Murray B. Urowitz
From the Division of Rheumatology, Department of Medicine, University of Toronto; Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; Dalla Lana School of Public Health, University of Toronto; Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario; and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval, Québec City, Québec, Canada. P.R. Fortin held the Distinguished Senior Investigator Award of the Arthritis Society and presently holds a Canada Research Chair in Systemic Autoimmune Rheumatic Diseases. Additional support was provided by the Arthritis Centre of Excellence, University of Toronto, and the Department of Medicine and Centre de recherche du centre hospitalier universitaire de Québec, Université Laval. CaNIOS is supported in part by Lupus Canada, Lupus Ontario, the Lupus Foundation of Ontario and BC Lupus as well as by the Toronto General and Western Hospital Foundation. Additional support was received from Bristol-Myers Squibb Canada Inc. The Centre for Prognostic Studies in Rheumatic Diseases University of Toronto Lupus Clinic is supported in part by The Smythe Foundation, Lupus Ontario, Dance for the Cure, Flare for Fashion, and the Lupus Foundation of Ontario. P.S. Akhavan, MD, Staff Rheumatologist, Division of Rheumatology, Department of Medicine, University of Toronto; J. Su, BSc, Research Analyst, Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; W. Lou, PhD, Professor of Biostatistics and Statistics, Canada Research Chair in Statistical Methods for Health Care, Dalla Lana School of Public Health, University of Toronto; D.D. Gladman, MD, FRCPC, Senior Scientist; M.B. Urowitz, MD, FRCPC, Senior Scientist, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto; P.R. Fortin, MD, MPH, FRCPC, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval. Address correspondence to Dr. P.R. Fortin, Centre de recherche du CHU de Québec, CHUL, Room S-763, 2705, boulevard Laurier, Québec City, QC G1V 4G2, Canada. E-mail: paul.fortin@crchuq.ulaval.ca Accepted for publication February 4, 2013.
Paul R. Fortin
From the Division of Rheumatology, Department of Medicine, University of Toronto; Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; Dalla Lana School of Public Health, University of Toronto; Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario; and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval, Québec City, Québec, Canada. P.R. Fortin held the Distinguished Senior Investigator Award of the Arthritis Society and presently holds a Canada Research Chair in Systemic Autoimmune Rheumatic Diseases. Additional support was provided by the Arthritis Centre of Excellence, University of Toronto, and the Department of Medicine and Centre de recherche du centre hospitalier universitaire de Québec, Université Laval. CaNIOS is supported in part by Lupus Canada, Lupus Ontario, the Lupus Foundation of Ontario and BC Lupus as well as by the Toronto General and Western Hospital Foundation. Additional support was received from Bristol-Myers Squibb Canada Inc. The Centre for Prognostic Studies in Rheumatic Diseases University of Toronto Lupus Clinic is supported in part by The Smythe Foundation, Lupus Ontario, Dance for the Cure, Flare for Fashion, and the Lupus Foundation of Ontario. P.S. Akhavan, MD, Staff Rheumatologist, Division of Rheumatology, Department of Medicine, University of Toronto; J. Su, BSc, Research Analyst, Division of Health Care and Outcome Research, Toronto Western Research Institute, University of Toronto; W. Lou, PhD, Professor of Biostatistics and Statistics, Canada Research Chair in Statistical Methods for Health Care, Dalla Lana School of Public Health, University of Toronto; D.D. Gladman, MD, FRCPC, Senior Scientist; M.B. Urowitz, MD, FRCPC, Senior Scientist, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto; P.R. Fortin, MD, MPH, FRCPC, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Health Care and Outcome Research, Toronto Western Research Institute, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, Department of Medicine, University Health Network, University of Toronto, and Division de Rhumatologie, Département de médecine, CHU de Québec and Université Laval. Address correspondence to Dr. P.R. Fortin, Centre de recherche du CHU de Québec, CHUL, Room S-763, 2705, boulevard Laurier, Québec City, QC G1V 4G2, Canada. E-mail: paul.fortin@crchuq.ulaval.ca Accepted for publication February 4, 2013.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
The Early Protective Effect of Hydroxychloroquine on the Risk of Cumulative Damage in Patients with Systemic Lupus Erythematosus
Pooneh S. Akhavan, Jiandong Su, Wendy Lou, Dafna D. Gladman, Murray B. Urowitz, Paul R. Fortin
The Journal of Rheumatology Apr 2013, jrheum.120572; DOI: 10.3899/jrheum.120572
The Early Protective Effect of Hydroxychloroquine on the Risk of Cumulative Damage in Patients with Systemic Lupus Erythematosus
Pooneh S. Akhavan, Jiandong Su, Wendy Lou, Dafna D. Gladman, Murray B. Urowitz, Paul R. Fortin
The Journal of Rheumatology Apr 2013, jrheum.120572; DOI: 10.3899/jrheum.120572