Research ArticleArticle
Do Changing Toll-like Receptor Profiles in Different Layers and Grades of Osteoarthritis Cartilage Reflect Disease Severity?
Gonçalo Barreto, Tarvo Sillat, Antti Soininen, Pekka Ylinen, Abdelhakim Salem, Yrjö T. Konttinen, Ahmed Al-Samadi and Dan C.E. Nordström
The Journal of Rheumatology March 2013, jrheum.121159; DOI: https://doi.org/10.3899/jrheum.121159
Gonçalo Barreto
From the Department of Medicine, University of Helsinki/Helsinki University Central Hospital, Helsinki; ORTON Orthopaedic Institute of the Invalid Foundation, Helsinki; COXA Hospital for Joint Replacement, Tampere; and the Department of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland. Supported by Finska Läkaresällskapet, the National Graduate School of Musculoskeletal Diseases and Biomaterials, Orion Farmos Research Foundation, evo grants, ORTON Orthopaedic Hospital of the Invalid Foundation, Sigrid Jusélius Foundation, Danish Council for Strategic Research, and the European Science Foundation “Regenerative Medicine” RNP. G. Barreto, MSc; T. Sillat, MD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; A. Soininen, PhD; P. Ylinen, MD, PhD, ORTON Orthopaedic Institute of the Invalid Foundation; A. Salem, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; Y.T. Konttinen, MD, PhD, Department of Medicine, University of Helsinki/Helsinki University Central Hospital; ORTON Orthopaedic Institute of the Invalid Foundation; COXA Hospital for Joint Replacement; A. Al-Samadi, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; D.C.E. Nordström, MD, PhD, Department of Rheumatology, Helsinki University Central Hospital. Address correspondence to Dr. D. Nordström, Institute of Clinical Medicine, Department of Medicine, Biomedicum 1, PO Box 700, FIN-00290 HUS, Finland. E-mail: dan.nordstrom@hus.fi Accepted for publication January 7, 2013.
Tarvo Sillat
From the Department of Medicine, University of Helsinki/Helsinki University Central Hospital, Helsinki; ORTON Orthopaedic Institute of the Invalid Foundation, Helsinki; COXA Hospital for Joint Replacement, Tampere; and the Department of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland. Supported by Finska Läkaresällskapet, the National Graduate School of Musculoskeletal Diseases and Biomaterials, Orion Farmos Research Foundation, evo grants, ORTON Orthopaedic Hospital of the Invalid Foundation, Sigrid Jusélius Foundation, Danish Council for Strategic Research, and the European Science Foundation “Regenerative Medicine” RNP. G. Barreto, MSc; T. Sillat, MD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; A. Soininen, PhD; P. Ylinen, MD, PhD, ORTON Orthopaedic Institute of the Invalid Foundation; A. Salem, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; Y.T. Konttinen, MD, PhD, Department of Medicine, University of Helsinki/Helsinki University Central Hospital; ORTON Orthopaedic Institute of the Invalid Foundation; COXA Hospital for Joint Replacement; A. Al-Samadi, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; D.C.E. Nordström, MD, PhD, Department of Rheumatology, Helsinki University Central Hospital. Address correspondence to Dr. D. Nordström, Institute of Clinical Medicine, Department of Medicine, Biomedicum 1, PO Box 700, FIN-00290 HUS, Finland. E-mail: dan.nordstrom@hus.fi Accepted for publication January 7, 2013.
Antti Soininen
From the Department of Medicine, University of Helsinki/Helsinki University Central Hospital, Helsinki; ORTON Orthopaedic Institute of the Invalid Foundation, Helsinki; COXA Hospital for Joint Replacement, Tampere; and the Department of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland. Supported by Finska Läkaresällskapet, the National Graduate School of Musculoskeletal Diseases and Biomaterials, Orion Farmos Research Foundation, evo grants, ORTON Orthopaedic Hospital of the Invalid Foundation, Sigrid Jusélius Foundation, Danish Council for Strategic Research, and the European Science Foundation “Regenerative Medicine” RNP. G. Barreto, MSc; T. Sillat, MD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; A. Soininen, PhD; P. Ylinen, MD, PhD, ORTON Orthopaedic Institute of the Invalid Foundation; A. Salem, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; Y.T. Konttinen, MD, PhD, Department of Medicine, University of Helsinki/Helsinki University Central Hospital; ORTON Orthopaedic Institute of the Invalid Foundation; COXA Hospital for Joint Replacement; A. Al-Samadi, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; D.C.E. Nordström, MD, PhD, Department of Rheumatology, Helsinki University Central Hospital. Address correspondence to Dr. D. Nordström, Institute of Clinical Medicine, Department of Medicine, Biomedicum 1, PO Box 700, FIN-00290 HUS, Finland. E-mail: dan.nordstrom@hus.fi Accepted for publication January 7, 2013.
Pekka Ylinen
From the Department of Medicine, University of Helsinki/Helsinki University Central Hospital, Helsinki; ORTON Orthopaedic Institute of the Invalid Foundation, Helsinki; COXA Hospital for Joint Replacement, Tampere; and the Department of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland. Supported by Finska Läkaresällskapet, the National Graduate School of Musculoskeletal Diseases and Biomaterials, Orion Farmos Research Foundation, evo grants, ORTON Orthopaedic Hospital of the Invalid Foundation, Sigrid Jusélius Foundation, Danish Council for Strategic Research, and the European Science Foundation “Regenerative Medicine” RNP. G. Barreto, MSc; T. Sillat, MD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; A. Soininen, PhD; P. Ylinen, MD, PhD, ORTON Orthopaedic Institute of the Invalid Foundation; A. Salem, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; Y.T. Konttinen, MD, PhD, Department of Medicine, University of Helsinki/Helsinki University Central Hospital; ORTON Orthopaedic Institute of the Invalid Foundation; COXA Hospital for Joint Replacement; A. Al-Samadi, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; D.C.E. Nordström, MD, PhD, Department of Rheumatology, Helsinki University Central Hospital. Address correspondence to Dr. D. Nordström, Institute of Clinical Medicine, Department of Medicine, Biomedicum 1, PO Box 700, FIN-00290 HUS, Finland. E-mail: dan.nordstrom@hus.fi Accepted for publication January 7, 2013.
Abdelhakim Salem
From the Department of Medicine, University of Helsinki/Helsinki University Central Hospital, Helsinki; ORTON Orthopaedic Institute of the Invalid Foundation, Helsinki; COXA Hospital for Joint Replacement, Tampere; and the Department of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland. Supported by Finska Läkaresällskapet, the National Graduate School of Musculoskeletal Diseases and Biomaterials, Orion Farmos Research Foundation, evo grants, ORTON Orthopaedic Hospital of the Invalid Foundation, Sigrid Jusélius Foundation, Danish Council for Strategic Research, and the European Science Foundation “Regenerative Medicine” RNP. G. Barreto, MSc; T. Sillat, MD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; A. Soininen, PhD; P. Ylinen, MD, PhD, ORTON Orthopaedic Institute of the Invalid Foundation; A. Salem, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; Y.T. Konttinen, MD, PhD, Department of Medicine, University of Helsinki/Helsinki University Central Hospital; ORTON Orthopaedic Institute of the Invalid Foundation; COXA Hospital for Joint Replacement; A. Al-Samadi, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; D.C.E. Nordström, MD, PhD, Department of Rheumatology, Helsinki University Central Hospital. Address correspondence to Dr. D. Nordström, Institute of Clinical Medicine, Department of Medicine, Biomedicum 1, PO Box 700, FIN-00290 HUS, Finland. E-mail: dan.nordstrom@hus.fi Accepted for publication January 7, 2013.
Yrjö T. Konttinen
From the Department of Medicine, University of Helsinki/Helsinki University Central Hospital, Helsinki; ORTON Orthopaedic Institute of the Invalid Foundation, Helsinki; COXA Hospital for Joint Replacement, Tampere; and the Department of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland. Supported by Finska Läkaresällskapet, the National Graduate School of Musculoskeletal Diseases and Biomaterials, Orion Farmos Research Foundation, evo grants, ORTON Orthopaedic Hospital of the Invalid Foundation, Sigrid Jusélius Foundation, Danish Council for Strategic Research, and the European Science Foundation “Regenerative Medicine” RNP. G. Barreto, MSc; T. Sillat, MD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; A. Soininen, PhD; P. Ylinen, MD, PhD, ORTON Orthopaedic Institute of the Invalid Foundation; A. Salem, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; Y.T. Konttinen, MD, PhD, Department of Medicine, University of Helsinki/Helsinki University Central Hospital; ORTON Orthopaedic Institute of the Invalid Foundation; COXA Hospital for Joint Replacement; A. Al-Samadi, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; D.C.E. Nordström, MD, PhD, Department of Rheumatology, Helsinki University Central Hospital. Address correspondence to Dr. D. Nordström, Institute of Clinical Medicine, Department of Medicine, Biomedicum 1, PO Box 700, FIN-00290 HUS, Finland. E-mail: dan.nordstrom@hus.fi Accepted for publication January 7, 2013.
Ahmed Al-Samadi
From the Department of Medicine, University of Helsinki/Helsinki University Central Hospital, Helsinki; ORTON Orthopaedic Institute of the Invalid Foundation, Helsinki; COXA Hospital for Joint Replacement, Tampere; and the Department of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland. Supported by Finska Läkaresällskapet, the National Graduate School of Musculoskeletal Diseases and Biomaterials, Orion Farmos Research Foundation, evo grants, ORTON Orthopaedic Hospital of the Invalid Foundation, Sigrid Jusélius Foundation, Danish Council for Strategic Research, and the European Science Foundation “Regenerative Medicine” RNP. G. Barreto, MSc; T. Sillat, MD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; A. Soininen, PhD; P. Ylinen, MD, PhD, ORTON Orthopaedic Institute of the Invalid Foundation; A. Salem, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; Y.T. Konttinen, MD, PhD, Department of Medicine, University of Helsinki/Helsinki University Central Hospital; ORTON Orthopaedic Institute of the Invalid Foundation; COXA Hospital for Joint Replacement; A. Al-Samadi, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; D.C.E. Nordström, MD, PhD, Department of Rheumatology, Helsinki University Central Hospital. Address correspondence to Dr. D. Nordström, Institute of Clinical Medicine, Department of Medicine, Biomedicum 1, PO Box 700, FIN-00290 HUS, Finland. E-mail: dan.nordstrom@hus.fi Accepted for publication January 7, 2013.
Dan C.E. Nordström
From the Department of Medicine, University of Helsinki/Helsinki University Central Hospital, Helsinki; ORTON Orthopaedic Institute of the Invalid Foundation, Helsinki; COXA Hospital for Joint Replacement, Tampere; and the Department of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland. Supported by Finska Läkaresällskapet, the National Graduate School of Musculoskeletal Diseases and Biomaterials, Orion Farmos Research Foundation, evo grants, ORTON Orthopaedic Hospital of the Invalid Foundation, Sigrid Jusélius Foundation, Danish Council for Strategic Research, and the European Science Foundation “Regenerative Medicine” RNP. G. Barreto, MSc; T. Sillat, MD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; A. Soininen, PhD; P. Ylinen, MD, PhD, ORTON Orthopaedic Institute of the Invalid Foundation; A. Salem, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; Y.T. Konttinen, MD, PhD, Department of Medicine, University of Helsinki/Helsinki University Central Hospital; ORTON Orthopaedic Institute of the Invalid Foundation; COXA Hospital for Joint Replacement; A. Al-Samadi, DMD, Institute of Clinical Medicine, Department of Medicine, University of Helsinki; D.C.E. Nordström, MD, PhD, Department of Rheumatology, Helsinki University Central Hospital. Address correspondence to Dr. D. Nordström, Institute of Clinical Medicine, Department of Medicine, Biomedicum 1, PO Box 700, FIN-00290 HUS, Finland. E-mail: dan.nordstrom@hus.fi Accepted for publication January 7, 2013.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Do Changing Toll-like Receptor Profiles in Different Layers and Grades of Osteoarthritis Cartilage Reflect Disease Severity?
Gonçalo Barreto, Tarvo Sillat, Antti Soininen, Pekka Ylinen, Abdelhakim Salem, Yrjö T. Konttinen, Ahmed Al-Samadi, Dan C.E. Nordström
The Journal of Rheumatology Mar 2013, jrheum.121159; DOI: 10.3899/jrheum.121159
Do Changing Toll-like Receptor Profiles in Different Layers and Grades of Osteoarthritis Cartilage Reflect Disease Severity?
Gonçalo Barreto, Tarvo Sillat, Antti Soininen, Pekka Ylinen, Abdelhakim Salem, Yrjö T. Konttinen, Ahmed Al-Samadi, Dan C.E. Nordström
The Journal of Rheumatology Mar 2013, jrheum.121159; DOI: 10.3899/jrheum.121159