Research ArticleArticle
Serum Interleukin 6 Is Predictive of Early Functional Decline and Mortality in Interstitial Lung Disease Associated with Systemic Sclerosis
Angelo De Lauretis, Piersante Sestini, Panagiotis Pantelidis, Rachel Hoyles, David M. Hansell, Nicole S.L. Goh, Christopher J. Zappala, Dina Visca, Toby M. Maher, Christopher P. Denton, Voon H. Ong, David J. Abraham, Peter Kelleher, Laureen Hector, Athol U. Wells and Elisabetta A. Renzoni
The Journal of Rheumatology February 2013, jrheum.120725; DOI: https://doi.org/10.3899/jrheum.120725
Angelo De Lauretis
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Piersante Sestini
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Panagiotis Pantelidis
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Rachel Hoyles
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
David M. Hansell
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Nicole S.L. Goh
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Christopher J. Zappala
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Dina Visca
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Toby M. Maher
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Christopher P. Denton
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Voon H. Ong
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
David J. Abraham
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Peter Kelleher
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Laureen Hector
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Athol U. Wells
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
Elisabetta A. Renzoni
From the Department of Pneumology, Carlo Poma Hospital, Mantua, Italy; Department of Pneumology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte,” Siena, Italy; Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK; Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital, London, UK; Department of Radiology, Royal Brompton Hospital, London, UK; Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; and the Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital, London, UK. Supported by the European Respiratory Society Short-Term Research Fellowship grant ERS-STRF 595 and by the Raynaud’s and Scleroderma Association; and by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. Dr. Sestini was supported by MIUR project no. 2008W7XP29. A. De Lauretis, MD, Department of Pneumology, Carlo Poma Hospital, Department of Pneumology, Università Cattolica del Sacro Cuore; P. Sestini, MD, Department of Respiratory Medicine, University of Siena, Ospedale “Le Scotte”; P. Pantelidis, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; R. Hoyles, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; D.M. Hansell, MD, FRCP, FRCR, Department of Radiology, Royal Brompton Hospital; N.S.L. Goh, MD, PhD, Respiratory and Sleep Medicine, Austin Health; C.J. Zappala, MD, FRACP, Interstitial Lung Disease Unit, Royal Brompton Hospital; D. Visca, MD, Department of Pneumology, Università Cattolica del Sacro Cuore; T.M. Maher, MRCP, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital; C.P. Denton, MD, PhD; V.H. Ong, PhD, MRCP; D.J. Abraham, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Hospital; P. Kelleher, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital; L. Hector, BSc, PhD, Infection and Immunity Laboratory, Imperial College Healthcare NHS Trust, Charing Cross Hospital; A.U. Wells, FRACP, MD, FRCP, FRCR; E.A. Renzoni, MD, PhD, Interstitial Lung Disease Unit, Royal Brompton Hospital. Address correspondence to Dr. E. Renzoni, Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK. E-mail: e.renzoni@imperial.ac.uk Accepted for publication December 4, 2012.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Serum Interleukin 6 Is Predictive of Early Functional Decline and Mortality in Interstitial Lung Disease Associated with Systemic Sclerosis
Angelo De Lauretis, Piersante Sestini, Panagiotis Pantelidis, Rachel Hoyles, David M. Hansell, Nicole S.L. Goh, Christopher J. Zappala, Dina Visca, Toby M. Maher, Christopher P. Denton, Voon H. Ong, David J. Abraham, Peter Kelleher, Laureen Hector, Athol U. Wells, Elisabetta A. Renzoni
The Journal of Rheumatology Feb 2013, jrheum.120725; DOI: 10.3899/jrheum.120725
Serum Interleukin 6 Is Predictive of Early Functional Decline and Mortality in Interstitial Lung Disease Associated with Systemic Sclerosis
Angelo De Lauretis, Piersante Sestini, Panagiotis Pantelidis, Rachel Hoyles, David M. Hansell, Nicole S.L. Goh, Christopher J. Zappala, Dina Visca, Toby M. Maher, Christopher P. Denton, Voon H. Ong, David J. Abraham, Peter Kelleher, Laureen Hector, Athol U. Wells, Elisabetta A. Renzoni
The Journal of Rheumatology Feb 2013, jrheum.120725; DOI: 10.3899/jrheum.120725