Research ArticleArticle
Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis
Maria Carmen Cénit, Carmen P. Simeón, Madelon C. Vonk, Jose L. Callejas-Rubio, Gerard Espinosa, Patricia Carreira, Francisco J. Blanco, Javier Narvaez, Carlos Tolosa, José A. Román-Ivorra, Inmaculada Gómez-García, Francisco J. García-Hernández, María Gallego, Rosa García-Portales, María Victoria Egurbide, Vicente Fonollosa, Paloma García de la Peña, Francisco J. López-Longo, Miguel A. González-Gay, the Spanish Scleroderma Group, Miguel A. González-Gay, the Spanish Scleroderma Group, Roger Hesselstrand, Gabriela Riemekasten, Torsten Witte, Alexandre E. Voskuyl, Annemie J. Schuerwegh, Rajan Madhok, Carmen Fonseca, Christopher Denton, Annika Nordin, Øyvind Palm, Jacob M. van Laar, Nicolas Hunzelmann, Jörg H.W. Distler, Alexander Kreuter, Ariane Herrick, Jane Worthington, Bobby P. Koeleman, Timothy R.D.J. Radstake and Javier Martín
The Journal of Rheumatology October 2012, jrheum.120506; DOI: https://doi.org/10.3899/jrheum.120506
Maria Carmen Cénit
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Carmen P. Simeón
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Madelon C. Vonk
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Jose L. Callejas-Rubio
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Gerard Espinosa
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Patricia Carreira
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Francisco J. Blanco
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Javier Narvaez
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Carlos Tolosa
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
José A. Román-Ivorra
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Inmaculada Gómez-García
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Francisco J. García-Hernández
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
María Gallego
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Rosa García-Portales
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
María Victoria Egurbide
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Vicente Fonollosa
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Paloma García de la Peña
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Francisco J. López-Longo
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Miguel A. González-Gay
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Miguel A. González-Gay
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Roger Hesselstrand
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Gabriela Riemekasten
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Torsten Witte
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Alexandre E. Voskuyl
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Annemie J. Schuerwegh
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Rajan Madhok
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Carmen Fonseca
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Christopher Denton
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Annika Nordin
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Øyvind Palm
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Jacob M. van Laar
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Nicolas Hunzelmann
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Jörg H.W. Distler
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Alexander Kreuter
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Ariane Herrick
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Jane Worthington
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Bobby P. Koeleman
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Timothy R.D.J. Radstake
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
Javier Martín
From the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada; Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain; Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Hospital Clínico Universitario, Granada; Department of Internal Medicine, Hospital Clínico de Barcelona, Barcelona; Department of Rheumatology, Hospital 12 de Octubre, Madrid; Complejo Hospitalario Universitario a Coruña, La Coruña; Department of Rheumatology, Hospital de Bellvitge, Barcelona; Department of Internal Medicine, Hospital Parc Tauli, Sabadell; Department of Rheumatology, Hospital La Fe, Valencia; Department of Rheumatology, Hospital Reina Sofía, Córdoba; Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla; Department of Internal Medicine, Hospital Central de Asturias, Oviedo; Department of Rheumatology, Hospital Virgen de la Victoria, Málaga; Department of Internal Medicine, Hospital de Cruces, Barakaldo; Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid; Department of Rheumatology, Hospital General Universitario Gregorio Marañón; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain; Department of Rheumatology, Lund University, Lund, Sweden; German Rheumatismus Research Centre, Leibniz Institute, Germany; Clinic for Immunology and Rheumatology Medical School, Hannover, Germany; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Rheumatic Disease University of Glasgow, Glasgow; Centre for Rheumatology, Royal Free and University College Medical School, London, UK; Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Cellular Medicine, Newcastle University, Newcastle, UK; Department of Dermatology, University of Cologne, Cologne; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen; Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, Germany; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Medical Genetics, University Medical Center Utrecht, Utrecht; and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The Netherlands. J. Martín was supported by GEN-FER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-180 from Junta de Andalucía, RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain, within the VI PN de I+D+i 2008-2011 (FEDER). T.R.D.J. Radstake and J. Martín are sponsored by the Orphan Disease Program grant from European League Against Rheumatism. N. Ortego-Centeno and J. Martín are supported by Consejería de Salud, Junta de Andalucía, PI-0590-2010. M.C. Cénit, PhD; J. Martín, MD, PhD, IPBLN-CSIC; C.P. Simeón, MD, PhD; V. Fonollosa, MD, PhD, Department of Internal Medicine, Hospital Valle de Hebron; M.C. Vonk, MD, PhD, Department of Rheumatology, Radboud University Nijmegen Medical Center; J.L. Callejas-Rubio, MD, PhD, Department of Internal Medicine, Hospital Clínico Universitario; G. Espinosa, MD, PhD, Department of Internal Medicine, Hospital Clínico de Barcelona; P. Carreira, MD, PhD, Department of Rheumatology, Hospital 12 de Octubre; F.J. Blanco, MD, PhD, Complejo Hospitalario Universitario a Coruña; J. Narvaez, MD, PhD, Department of Rheumatology, Hospital de Bellvitge; C. Tolosa, MD, PhD, Department of Internal Medicine, Hospital Parc Tauli; J.A. Román-Ivorra, MD, PhD, Department of Rheumatology, Hospital La Fe; I. Gómez-García, MD, PhD, Department of Rheumatology, Hospital Reina Sofía, Córdoba; F.J. García-Hernández, MD, PhD, Department of Internal Medicine, Hospital Virgen del Rocío; M. Gallego, MD, PhD, Department of Internal Medicine, Hospital Central de Asturias; R. García-Portales, MD, PhD, Department of Rheumatology, Hospital Virgen de la Victoria; M.V. Egurbide, MD, PhD, Department of Internal Medicine, Hospital de Cruces; P. García de la Peña, MD, PhD, Department of Rheumatology, Hospital Madrid Norte Sanchinarro; F.J. López-Longo, MD, PhD, Department of Rheumatology, Hospital General Universitario Gregorio Marañón; M.A. González-Gay, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV; R. Hesselstrand, MD, PhD, Department of Rheumatology, Lund University; G. Riemekasten, MD, PhD, German Rheumatismus Research Centre, Leibniz Institute; T. Witte, MD, PhD, Clinic for Immunology and Rheumatology Medical School; A.E. Voskuyl, MD, PhD, Department of Rheumatology, VU University Medical Center; A.J. Schuerwegh, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Madhok, MD, PhD, Centre for Rheumatic Disease University of Glasgow; C. Fonseca, MD, PhD; C. Denton, MD, PhD, Centre for Rheumatology, Royal Free and University College Medical School; A. Nordin, MD, PhD, Center for Molecular Medicine, Karolinska Institute; Ø. Palm, MD, PhD, Department of Rheumatology, Rikshospitalet, Oslo University Hospital; J.M. van Laar, MD, PhD, Institute of Cellular Medicine, Newcastle University; N. Hunzelmann, MD, PhD, Department of Dermatology, University of Cologne; J.H.W. Distler, MD, PhD, Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg; A. Kreuter, MD, PhD, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum; A. Herrick, MD, PhD; J. Worthington, MD, PhD, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre; B.P. Koeleman, MD, PhD, Department of Medical Genetics, University Medical Center Utrecht; T.R.D.J. Radstake, MD, PhD, Department of Rheumatology and Clinical Immunology, Utrecht Medical Center. Address correspondence to M.C. Cénit, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento, s/n 18100 Armilla, Granada, Spain. E-mail: mccenit@ipb.csic.es Accepted for publication July 4, 2012.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis
Maria Carmen Cénit, Carmen P. Simeón, Madelon C. Vonk, Jose L. Callejas-Rubio, Gerard Espinosa, Patricia Carreira, Francisco J. Blanco, Javier Narvaez, Carlos Tolosa, José A. Román-Ivorra, Inmaculada Gómez-García, Francisco J. García-Hernández, María Gallego, Rosa García-Portales, María Victoria Egurbide, Vicente Fonollosa, Paloma García de la Peña, Francisco J. López-Longo, Miguel A. González-Gay, the Spanish Scleroderma Group, Miguel A. González-Gay, the Spanish Scleroderma Group, Roger Hesselstrand, Gabriela Riemekasten, Torsten Witte, Alexandre E. Voskuyl, Annemie J. Schuerwegh, Rajan Madhok, Carmen Fonseca, Christopher Denton, Annika Nordin, Øyvind Palm, Jacob M. van Laar, Nicolas Hunzelmann, Jörg H.W. Distler, Alexander Kreuter, Ariane Herrick, Jane Worthington, Bobby P. Koeleman, Timothy R.D.J. Radstake, Javier Martín
The Journal of Rheumatology Oct 2012, jrheum.120506; DOI: 10.3899/jrheum.120506
Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis
Maria Carmen Cénit, Carmen P. Simeón, Madelon C. Vonk, Jose L. Callejas-Rubio, Gerard Espinosa, Patricia Carreira, Francisco J. Blanco, Javier Narvaez, Carlos Tolosa, José A. Román-Ivorra, Inmaculada Gómez-García, Francisco J. García-Hernández, María Gallego, Rosa García-Portales, María Victoria Egurbide, Vicente Fonollosa, Paloma García de la Peña, Francisco J. López-Longo, Miguel A. González-Gay, the Spanish Scleroderma Group, Miguel A. González-Gay, the Spanish Scleroderma Group, Roger Hesselstrand, Gabriela Riemekasten, Torsten Witte, Alexandre E. Voskuyl, Annemie J. Schuerwegh, Rajan Madhok, Carmen Fonseca, Christopher Denton, Annika Nordin, Øyvind Palm, Jacob M. van Laar, Nicolas Hunzelmann, Jörg H.W. Distler, Alexander Kreuter, Ariane Herrick, Jane Worthington, Bobby P. Koeleman, Timothy R.D.J. Radstake, Javier Martín
The Journal of Rheumatology Oct 2012, jrheum.120506; DOI: 10.3899/jrheum.120506