Research ArticleArticle
Anti-DFS70/LEDGF Antibodies Are More Prevalent in Healthy Individuals Compared to Patients with Systemic Autoimmune Rheumatic Diseases
Michael Mahler, Todd Parker, Carol L. Peebles, Luis E. Andrade, Andreas Swart, Yvette Carbone, David J. Ferguson, Danilo Villalta, Nicola Bizzaro, John G. Hanly and Marvin J. Fritzler
The Journal of Rheumatology September 2012, jrheum.120598; DOI: https://doi.org/10.3899/jrheum.120598
Michael Mahler
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
Todd Parker
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
Carol L. Peebles
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
Luis E. Andrade
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
Andreas Swart
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
Yvette Carbone
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
David J. Ferguson
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
Danilo Villalta
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
Nicola Bizzaro
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
John G. Hanly
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
Marvin J. Fritzler
From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory. M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de Accepted for publication July 3, 2012.
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- Published online September 1, 2012.
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© 2012 The Journal of Rheumatology
Author Information
- Michael Mahler,
- Todd Parker,
- Carol L. Peebles,
- Luis E. Andrade,
- Andreas Swart,
- Yvette Carbone,
- David J. Ferguson,
- Danilo Villalta,
- Nicola Bizzaro,
- John G. Hanly and
- Marvin J. Fritzler
- From the Department of Research, Inova Diagnostics Inc., San Diego, California, USA; Fleury Medicine and Health Laboratory, Sao Paulo, SP, Brazil; Neuss Center for Rheumatology, Neuss, Germany; BC Biomedical Laboratories Ltd., Surrey, British Columbia, Canada; Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli, Pordenone, Italy; Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy; Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
M. Mahler, C.L. Peebles, and T. Parker are employees of Inova Diagnostics Inc. M.J. Fritzler is a paid consultant of Inova Diagnostics Inc. and ImmunoConcepts and is the director of Mitogen Advanced Diagnostics Laboratory.
M. Mahler, PhD; T. Parker, BS; C.L. Peebles, MS, Department of Research, Inova Diagnostics Inc.; L.E. Andrade, PhD, Fleury Medicine and Health Laboratory; A. Swart, MS, Neuss Center for Rheumatology; Y. Carbone, RT; D.J. Ferguson, MD, BC Biomedical Laboratories Ltd.; D. Villalta, MD, Department of Allergology and Clinical Immunology, AO S. Maria degli Angeli; N. Bizzaro, MD, Laboratory of Clinical Pathology, San Antonio Hospital; J.G. Hanly, MD, Faculty of Medicine, Dalhousie University; M.J. Fritzler, PhD, MD, Faculty of Medicine, University of Calgary.
Address correspondence to Dr. M. Mahler, Inova Diagnostics Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA. E-mail: mmahler@inovadx.com or m.mahler.job@web.de
Accepted for publication July 3, 2012.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Anti-DFS70/LEDGF Antibodies Are More Prevalent in Healthy Individuals Compared to Patients with Systemic Autoimmune Rheumatic Diseases
Michael Mahler, Todd Parker, Carol L. Peebles, Luis E. Andrade, Andreas Swart, Yvette Carbone, David J. Ferguson, Danilo Villalta, Nicola Bizzaro, John G. Hanly, Marvin J. Fritzler
The Journal of Rheumatology Sep 2012, jrheum.120598; DOI: 10.3899/jrheum.120598
Anti-DFS70/LEDGF Antibodies Are More Prevalent in Healthy Individuals Compared to Patients with Systemic Autoimmune Rheumatic Diseases
Michael Mahler, Todd Parker, Carol L. Peebles, Luis E. Andrade, Andreas Swart, Yvette Carbone, David J. Ferguson, Danilo Villalta, Nicola Bizzaro, John G. Hanly, Marvin J. Fritzler
The Journal of Rheumatology Sep 2012, jrheum.120598; DOI: 10.3899/jrheum.120598