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Research ArticleOMERACT 2016 — International Consensus Conference on Outcome Measures in Rheumatology, Whistler, British Columbia, Canada, May 2016

The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions

Kathryn S. Stok, Stephanie Finzel, Andrew J. Burghardt, Philip G. Conaghan and Cheryl Barnabe for the SPECTRA Collaboration
The Journal of Rheumatology December 2017, 44 (12) 1911-1915; DOI: https://doi.org/10.3899/jrheum.161197
Kathryn S. Stok
From the Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Department of Biomedical Engineering, University of Melbourne, Melbourne, Victoria, Australia; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK; Departments of Medicine and Community Health Sciences, University of Calgary; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.K.S. Stok, PhD, Senior Lecturer, Institute for Biomechanics, ETH Zurich, and Department of Biomedical Engineering, University of Melbourne; S. Finzel, MD, Senior Attending Physician, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg; A.J. Burghardt, BS, Research Specialist, Department of Radiology and Biomedical Imaging, University of California; P.G. Conaghan, MD, PhD, Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre; C. Barnabe, MD, MSc, Associate Professor, Departments of Medicine and Community Health Sciences, University of Calgary, and McCaig Institute for Bone and Joint Health, University of Calgary.
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  • For correspondence: kstok@unimelb.edu.au
Stephanie Finzel
From the Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Department of Biomedical Engineering, University of Melbourne, Melbourne, Victoria, Australia; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK; Departments of Medicine and Community Health Sciences, University of Calgary; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.K.S. Stok, PhD, Senior Lecturer, Institute for Biomechanics, ETH Zurich, and Department of Biomedical Engineering, University of Melbourne; S. Finzel, MD, Senior Attending Physician, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg; A.J. Burghardt, BS, Research Specialist, Department of Radiology and Biomedical Imaging, University of California; P.G. Conaghan, MD, PhD, Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre; C. Barnabe, MD, MSc, Associate Professor, Departments of Medicine and Community Health Sciences, University of Calgary, and McCaig Institute for Bone and Joint Health, University of Calgary.
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Andrew J. Burghardt
From the Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Department of Biomedical Engineering, University of Melbourne, Melbourne, Victoria, Australia; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK; Departments of Medicine and Community Health Sciences, University of Calgary; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.K.S. Stok, PhD, Senior Lecturer, Institute for Biomechanics, ETH Zurich, and Department of Biomedical Engineering, University of Melbourne; S. Finzel, MD, Senior Attending Physician, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg; A.J. Burghardt, BS, Research Specialist, Department of Radiology and Biomedical Imaging, University of California; P.G. Conaghan, MD, PhD, Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre; C. Barnabe, MD, MSc, Associate Professor, Departments of Medicine and Community Health Sciences, University of Calgary, and McCaig Institute for Bone and Joint Health, University of Calgary.
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Philip G. Conaghan
From the Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Department of Biomedical Engineering, University of Melbourne, Melbourne, Victoria, Australia; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK; Departments of Medicine and Community Health Sciences, University of Calgary; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.K.S. Stok, PhD, Senior Lecturer, Institute for Biomechanics, ETH Zurich, and Department of Biomedical Engineering, University of Melbourne; S. Finzel, MD, Senior Attending Physician, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg; A.J. Burghardt, BS, Research Specialist, Department of Radiology and Biomedical Imaging, University of California; P.G. Conaghan, MD, PhD, Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre; C. Barnabe, MD, MSc, Associate Professor, Departments of Medicine and Community Health Sciences, University of Calgary, and McCaig Institute for Bone and Joint Health, University of Calgary.
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Cheryl Barnabe
From the Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Department of Biomedical Engineering, University of Melbourne, Melbourne, Victoria, Australia; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK; Departments of Medicine and Community Health Sciences, University of Calgary; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.K.S. Stok, PhD, Senior Lecturer, Institute for Biomechanics, ETH Zurich, and Department of Biomedical Engineering, University of Melbourne; S. Finzel, MD, Senior Attending Physician, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg; A.J. Burghardt, BS, Research Specialist, Department of Radiology and Biomedical Imaging, University of California; P.G. Conaghan, MD, PhD, Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre; C. Barnabe, MD, MSc, Associate Professor, Departments of Medicine and Community Health Sciences, University of Calgary, and McCaig Institute for Bone and Joint Health, University of Calgary.
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Abstract

Objective. High-resolution peripheral quantitative computed tomography (HR-pQCT) has the potential to improve radiographic progression determination in clinical trials and longitudinal observational studies. The goal of this work was to describe the current state of research presented at Outcome Measures in Rheumatology (OMERACT) 2016 and ensuing future directions outlined during discussion among attendees.

Methods. At OMERACT 2016, SPECTRA (Study grouP for xtrEme-Computed Tomography in Rheumatoid Arthritis) introduced efforts to (1) validate the HR-pQCT according to OMERACT guidelines, focusing on rheumatoid arthritis (RA), and (2) find alternatives for automated joint space width (JSW) analysis. The Special Interest Group (SIG) was presented to patient research partners, physicians/researchers, and SIG leaders followed by a 40-min discussion on future directions.

Results. A consensus definition for RA erosion using HR-pQCT was demonstrated through a systematic literature review and a Delphi exercise. Histopathology and perfusion studies were presented that analyzed the true characteristics of cortical breaks in HR-pQCT images, and to provide criterion validity. Results indicate that readers were able to discriminate between erosion and small vascular channels. Moderate reliability (ICC 0.206–0.871) of direct erosion size measures was shown, which improved (> 0.9) only when experienced readers were considered. Quantification of erosion size was presented for scoring, direct measurement, and volumetric approaches, as well as a reliability exercise for direct measurement. Three methods for JSW measurement were compared, all indicating excellent reproducibility with differences at the extremes (i.e., near-zero and joint edge thickness).

Conclusion. Initial reports on HR-pQCT are promising; however, to consider its use in clinical trials and longitudinal observational studies, it is imperative to assess the responsiveness of erosion measurement quantification.

Key Indexing Terms:
  • RADIOGRAPHIC COMPUTED TOMOGRAPHY
  • 3-D IMAGING
  • RHEUMATOID ARTHRITIS
  • METACARPOPHALANGEAL JOINT
  • OMERACT

Footnotes

  • PGC is supported in part by the NIHR Leeds Biomedical Research Centre.

  • Accepted for publication June 3, 2017.
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1 Dec 2017
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The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions
Kathryn S. Stok, Stephanie Finzel, Andrew J. Burghardt, Philip G. Conaghan, Cheryl Barnabe
The Journal of Rheumatology Dec 2017, 44 (12) 1911-1915; DOI: 10.3899/jrheum.161197

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The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions
Kathryn S. Stok, Stephanie Finzel, Andrew J. Burghardt, Philip G. Conaghan, Cheryl Barnabe
The Journal of Rheumatology Dec 2017, 44 (12) 1911-1915; DOI: 10.3899/jrheum.161197
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Keywords

RADIOGRAPHIC COMPUTED TOMOGRAPHY
3-D IMAGING
RHEUMATOID ARTHRITIS
METACARPOPHALANGEAL JOINT
OMERACT

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OMERACT 2016 — International Consensus Conference on Outcome Measures in Rheumatology, Whistler, British Columbia, Canada, May 2016

  • Developing an OMERACT Core Outcome Set for Assessing Safety Components in Rheumatology Trials: The OMERACT Safety Working Group
  • Stiffness Is the Cardinal Symptom of Inflammatory Musculoskeletal Diseases, Yet Still Variably Measured: Report from the OMERACT 2016 Stiffness Special Interest Group
  • Critical Outcomes in Longitudinal Observational Studies and Registries in Patients with Rheumatoid Arthritis: An OMERACT Special Interest Group Report
Show more OMERACT 2016 — International Consensus Conference on Outcome Measures in Rheumatology, Whistler, British Columbia, Canada, May 2016

Special Interest Groups, Part 2

  • Stiffness Is the Cardinal Symptom of Inflammatory Musculoskeletal Diseases, Yet Still Variably Measured: Report from the OMERACT 2016 Stiffness Special Interest Group
  • Critical Outcomes in Longitudinal Observational Studies and Registries in Patients with Rheumatoid Arthritis: An OMERACT Special Interest Group Report
  • Development of a Core Set of Outcome Measures for Large-vessel Vasculitis: Report from OMERACT 2016
Show more Special Interest Groups, Part 2

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Keywords

  • RADIOGRAPHIC COMPUTED TOMOGRAPHY
  • 3-D IMAGING
  • RHEUMATOID ARTHRITIS
  • METACARPOPHALANGEAL JOINT
  • OMERACT

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