Abstract
Objective. To assess the effect of glucocorticoids (GC) on damage progression in placebo-biologic arms of rheumatoid arthritis (RA) biologics trials.
Methods. Posthoc metaanalysis of 2 infliximab (IFX) trials (established and early RA) and 1 tocilizumab (TCZ) trial (established RA).
Results. The proportion of patients receiving GC was 38%–64%, baseline damage was 11–82 Sharp/van der Heijde points, and progression in the placebo groups was 0.5–4.8 points in 6 months. In the pooled IFX studies, GC cotreatment reduced 6-month progression by 2.6 points (95% CI 0.6–4.5). In the TCZ study (progression rate 0.5 Genant points), no such difference was seen.
Conclusion. GC cotreatment may affect results in RA trials.
- Accepted for publication February 19, 2016.