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Research ArticleArticle

Breastfeeding and Risk of Rheumatoid Arthritis: A Systematic Review and Metaanalysis

Haiyan Chen, Jing Wang, Wang Zhou, Huabin Yin and Meimei Wang
The Journal of Rheumatology September 2015, 42 (9) 1563-1569; DOI: https://doi.org/10.3899/jrheum.150195
Haiyan Chen
From the Division of Rheumatology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing; Department of Anatomy and Histoembryology, Xuzhou Medical College, Xuzhou; Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
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Jing Wang
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Wang Zhou
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Huabin Yin
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Meimei Wang
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  • For correspondence: wmm3272142@163.com
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Abstract

Objective. Previous studies have examined the association between breastfeeding and rheumatoid arthritis (RA), but their results were inconsistent. The aim of this study was to perform a metaanalysis to clarify the effect of breastfeeding on RA risk.

Methods. The PubMed, EMBASE, Chinese National Knowledge Infrastructure, and Wanfang databases were searched for relevant studies published up to September 10, 2014. Data were extracted, and multivariable-adjusted OR with 95% CI were pooled in the random-effects model.

Results. A total of 6 studies were included in the metaanalysis (RA cases: 1672, sample size: 143,670). Overall, an inverse association between breastfeeding and RA was observed (OR 0.675, 95% CI 0.493–0.924, p = 0.014). In the subgroup analysis, decreased RA risk was also found in both breastfeeding 1–12 months (OR 0.783, 95% CI 0.641–0.957, p = 0.015) and breastfeeding > 12 months (OR 0.579, 95% CI 0.462–0.726, p < 0.0005). Sensitivity analysis and cumulative analysis further strengthened the validity of the results. No publication bias was found in this metaanalysis.

Conclusion. This metaanalysis suggests that breastfeeding is associated with a lower risk of RA, no matter if breastfeeding time is longer or shorter than 12 months.

Key Indexing Terms:
  • RHEUMATOID ARTHRITIS
  • BREASTFEEDING
  • RISK
  • METAANALYSIS

Footnotes

  • Supported by the National Natural Science Foundation of China (81401355).

  • Accepted for publication May 21, 2015.
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The Journal of Rheumatology
Vol. 42, Issue 9
1 Sep 2015
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Breastfeeding and Risk of Rheumatoid Arthritis: A Systematic Review and Metaanalysis
Haiyan Chen, Jing Wang, Wang Zhou, Huabin Yin, Meimei Wang
The Journal of Rheumatology Sep 2015, 42 (9) 1563-1569; DOI: 10.3899/jrheum.150195

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Breastfeeding and Risk of Rheumatoid Arthritis: A Systematic Review and Metaanalysis
Haiyan Chen, Jing Wang, Wang Zhou, Huabin Yin, Meimei Wang
The Journal of Rheumatology Sep 2015, 42 (9) 1563-1569; DOI: 10.3899/jrheum.150195
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Keywords

RHEUMATOID ARTHRITIS
BREASTFEEDING
RISK
METAANALYSIS

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Keywords

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  • BREASTFEEDING
  • RISK
  • METAANALYSIS

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