Abstract
Objective. Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population.
Methods. Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls.
Results. cGKII variants have no association with gout.
Conclusion. Our replication study suggests that cGKII is not involved in gout susceptibility.
Footnotes
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Supported by grants from the Ministry of Education, Science, and Culture of Japan; the Ministry of Health, Labor, and Welfare of Japan; the Ministry of Defense of Japan; the Japan Society for the Promotion of Science; Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics; the AstraZeneca VRI Research Grant; the Takeda Science Foundation; and the Gout Research Foundation of Japan.
- Accepted for publication March 14, 2014.
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