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Research ArticleArticle

Joint Effects of Alcohol Consumption and ABCG2 Q141K on Chronic Tophaceous Gout Risk

Hung-Pin Tu, Albert Min-Shan Ko, Shang-Lun Chiang, Su-Shin Lee, Han-Ming Lai, Chia-Min Chung, Chung-Ming Huang, Chien-Hung Lee, Tzer-Min Kuo, Mei-Jung Hsieh and Ying-Chin Ko
The Journal of Rheumatology April 2014, 41 (4) 749-758; DOI: https://doi.org/10.3899/jrheum.130870
Hung-Pin Tu
From the Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, and Department of Accounting, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany; Environment-Omics-Disease Research Centre, and Graduate Institute of Integrated Medicine, and the Graduate Institute of Clinical Medical Science, China Medical University Hospital, Taichung, Taiwan; Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.
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Albert Min-Shan Ko
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Shang-Lun Chiang
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Su-Shin Lee
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Han-Ming Lai
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Chia-Min Chung
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Chung-Ming Huang
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Chien-Hung Lee
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Tzer-Min Kuo
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Mei-Jung Hsieh
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Ying-Chin Ko
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  • For correspondence: ycko0406@gmail.com
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Abstract

Objective. To investigate the joint effects of alcohol consumption and ABCG2 gene variants on tophaceous gout occurrence.

Methods. The V12M (rs2231137), Q126X (rs72552713), and Q141K (rs2231142) of the ABCG2 gene were genotyped among controls, nontophaceous, and tophaceous gout cases in Taiwanese Han (n = 446, 77, 177) and Taiwan Aborigines (n = 1105, 203, 330).

Results. The missense variations V12M (C) and Q141K (T) significantly associated with tophaceous gout (p trend = 4.08 × 10−2, 9.00 × 10−12 in Han; 1.81 × 10−3, 9.34 × 10−10 in Aborigines). The nonsense variation Q126X (T) exerted a significant effect only in Han (p = 1.10 × 10−2), but not in Aborigines. In the prediction of tophaceous gout, the Q141K (T) OR were 1.51 in Han, 1.50 in Aborigines, and 1.55 (p = 7.84 × 10−5) in pooled analysis when compared to nontophaceous gout. We found the joint effects of alcohol consumption and Q141K (T/T) highly associated with tophaceous gout (adjusted OR ≥ 5.11; p ≤ 7.78 × 10−4); specifically the ever drinkers carrying the Q141K (T/T; adjusted OR 25.05, p = 9.21 × 10−4 in Han; adjusted OR 14.87, p = 1.08 × 10−8 in Aborigines).

Conclusion. Our findings showed alcohol consumption and ABCG2 Q141K, independently and jointly, associated with the risk of chronic tophaceous gout.

Key Indexing Terms:
  • TOPHACEOUS GOUT
  • ALCOHOL CONSUMPTION
  • ABCG2 Q141K

Footnotes

  • Supported by the Taiwan National Health Research Institutes (NHRI-98A1-PDCO-0307101), the Taiwanese National Science Council (NSC97-2314-B-039-007-MY3 and NSC99-2628-B-037-039-MY3), and the Kaohsiung Medical University (KMU-Q102006, KMU-M103018).

  • Accepted for publication December 13, 2013.
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The Journal of Rheumatology
Vol. 41, Issue 4
1 Apr 2014
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Joint Effects of Alcohol Consumption and ABCG2 Q141K on Chronic Tophaceous Gout Risk
Hung-Pin Tu, Albert Min-Shan Ko, Shang-Lun Chiang, Su-Shin Lee, Han-Ming Lai, Chia-Min Chung, Chung-Ming Huang, Chien-Hung Lee, Tzer-Min Kuo, Mei-Jung Hsieh, Ying-Chin Ko
The Journal of Rheumatology Apr 2014, 41 (4) 749-758; DOI: 10.3899/jrheum.130870

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Joint Effects of Alcohol Consumption and ABCG2 Q141K on Chronic Tophaceous Gout Risk
Hung-Pin Tu, Albert Min-Shan Ko, Shang-Lun Chiang, Su-Shin Lee, Han-Ming Lai, Chia-Min Chung, Chung-Ming Huang, Chien-Hung Lee, Tzer-Min Kuo, Mei-Jung Hsieh, Ying-Chin Ko
The Journal of Rheumatology Apr 2014, 41 (4) 749-758; DOI: 10.3899/jrheum.130870
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Keywords

TOPHACEOUS GOUT
ALCOHOL CONSUMPTION
ABCG2 Q141K

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