Abstract
Objective. To identify soluble biomarkers associated with response to therapy with tumor necrosis factor inhibitors (TNFi) in patients with psoriatic arthritis (PsA).
Methods. The study was conducted at a PsA clinic where patients are assessed every 6 months, and serum samples are collected and stored once a year at the time of clinical assessment. Forty patients with active PsA who gave serum samples prior to treatment with TNFi and after at least 3 months of therapy were identified. Patients were classified as TNFi responders if tender joint count was < 3, swollen joint count was 0, and Psoriasis Area and Severity Index score was < 4 at the time the second sample was collected. The following biomarkers were tested by ELISA: TNF superfamily 14, matrix metalloprotease-3 (MMP-3), receptor activator of nuclear factor kappa-B ligand, osteoprotegerin, cartilage oligomeric matrix protein (COMP), CPII, C2C and C1-2C, CS-846, and highly sensitive C-reactive protein. Paired t tests and logistic regression was used for statistical analyses.
Results. After a mean treatment duration of 11 months with TNFi (etanercept 28 patients, adalimumab 6, golimumab 4, infliximab 2), 29 patients were classified as TNFi responders. Baseline level of MMP-3 was independently associated with responder status (OR 1.067 for each 1-unit increase, p = 0.045). A reduction in MMP-3 levels with therapy increased the odds of achieving response (OR 1.213 for each 1-unit change, p = 0.030), whereas a reduction in COMP decreased the odds (OR 0.587, for each 100-unit increase, p = 0.039). None of the other biomarkers was associated with response.
Conclusion. Baseline as well as reduction in serum MMP-3 and increase in serum COMP are independently associated with response to TNFi therapy in patients with PsA.
Footnotes
-
Supported in part by a grant from The Arthritis Society, the Canadian Institutes of Health Research (CIHR) Institute of Musculoskeletal Health and Arthritis, and the Krembil Foundation. Dr. Chandran was supported by a CIHR Clinical Research Initiative Fellowship and by the Krembil Foundation. He has received research funds from Abbott Canada, and has also received honoraria from Abbott Canada, Amgen/Pfizer Canada, Janssen Canada, Merck Canada, and Bristol-Myers Squibb Canada. Dr. Cook is a Canada Research Chair in Statistical Methods for Health Research and is supported by the CIHR. Dr. Gladman has received research grants from Abbott Canada, Amgen Canada, and Janssen, and has served as consultant to Abbott, Amgen, BMS, Centocor, Janssen, Pfizer, and UCB.
- Accepted for publication February 14, 2013.