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Research ArticleArticle

HLA-B27 Prevalence in Arab Populations and Among Patients with Ankylosing Spondylitis

KHADER N. MUSTAFA, MOHAMMED HAMMOUDEH and MUHAMMAD ASIM KHAN
The Journal of Rheumatology August 2012, 39 (8) 1675-1677; DOI: https://doi.org/10.3899/jrheum.120403
KHADER N. MUSTAFA
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  • For correspondence: kmustafa@ju.edu.jo
MOHAMMED HAMMOUDEH
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MUHAMMAD ASIM KHAN
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Abstract

Objective. To investigate prevalence of HLA-B27 among general Arab populations and among patients with ankylosing spondylitis (AS), and to review published data.

Methods. The prevalence of HLA-B27 was studied among 2579 unrelated healthy Jordanians, almost equally divided among Palestinian refugees and natives of Jordan, reflecting the general population of Jordan. The prevalence of HLA-B27 was also studied among 129 patients with AS, 70 from Jordan, and the remaining 59 from Qatar. HLA typing was performed by standard 2-stage micro-lymphocytotoxicity method. We also reviewed published English language studies of HLA-B27 in Arab patients with AS and general populations retrieved through Medline and cross-reference search.

Results. We observed that the general prevalence of HLA-B27 among Jordanians is 2.4%; while the reported prevalence ranges between 2% and 5% among major Arab populations. The prevalence of HLA-B27 among patients with AS is 71% in Jordan and 73% in Qatar, while the reported prevalence from pooled published data from various Arab populations is 64%.

Conclusion. From these data one can conclude that HLA-B27 is present in about 2% to 5% among major Arab populations and that its prevalence in Arab patients with AS is closer to 70%.

Key Indexing Terms:
  • HLA-B27
  • ANKYLOSING SPONDYLITIS
  • ARABS
  • PREVALENCE
  • MIDDLE EAST
  • NORTH AFRICA
  • Accepted for publication May 7, 2012.
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The Journal of Rheumatology
Vol. 39, Issue 8
1 Aug 2012
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HLA-B27 Prevalence in Arab Populations and Among Patients with Ankylosing Spondylitis
KHADER N. MUSTAFA, MOHAMMED HAMMOUDEH, MUHAMMAD ASIM KHAN
The Journal of Rheumatology Aug 2012, 39 (8) 1675-1677; DOI: 10.3899/jrheum.120403

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HLA-B27 Prevalence in Arab Populations and Among Patients with Ankylosing Spondylitis
KHADER N. MUSTAFA, MOHAMMED HAMMOUDEH, MUHAMMAD ASIM KHAN
The Journal of Rheumatology Aug 2012, 39 (8) 1675-1677; DOI: 10.3899/jrheum.120403
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