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Research ArticleOMERACT 10: 10th International Consensus Conference on Outcome Measures in Rheumatology, Kota Kinabalu, Borneo - May 4–8, 2010

It's Good to Feel Better But It's Better To Feel Good and Even Better to Feel Good as Soon as Possible for as Long as Possible. Response Criteria and the Importance of Change at OMERACT 10

VIBEKE STRAND, MAARTEN BOERS, LEANNE IDZERDA, JOHN R. KIRWAN, TORE K. KVIEN, PETER S. TUGWELL and MAXIME DOUGADOS
The Journal of Rheumatology August 2011, 38 (8) 1720-1727; DOI: https://doi.org/10.3899/jrheum.110392
VIBEKE STRAND
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MAARTEN BOERS
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LEANNE IDZERDA
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  • For correspondence: lidzerda@uottawa.ca
JOHN R. KIRWAN
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TORE K. KVIEN
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PETER S. TUGWELL
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MAXIME DOUGADOS
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Abstract

The OMERACT patient reported outcomes (PRO) working group evaluated the methodologies for measuring responsiveness to change at the Outcome Measures in Rheumatology (OMERACT) 10 meeting. The outcome measures used in PRO studies are often expressed as continuous data at the group level (e.g., mean change in pain on a 0–100 visual analog scale). This is difficult to interpret and cannot easily be translated to the individual level of response. When interpreting scores at the individual level, it is important to take into account the following 4 main concepts: (1) improvement; (2) status of well-being; (3) onset of action; and (4) sustainability. Information from clinical trials on how many patients showed a response, what the level of response was, and how many patients are doing well, would be extremely useful for physicians. The objective of this article is to outline how continuous data may be reported in a clinically relevant manner. We will describe 5 techniques of reporting continuous variables in clinical studies and discuss the relevance of each.

Key Indexing Terms:
  • RESPONSE TO CHANGE
  • CLINICIANS
  • OUTCOMES
  • RESPONSIVENESS
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The Journal of Rheumatology
Vol. 38, Issue 8
1 Aug 2011
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It's Good to Feel Better But It's Better To Feel Good and Even Better to Feel Good as Soon as Possible for as Long as Possible. Response Criteria and the Importance of Change at OMERACT 10
VIBEKE STRAND, MAARTEN BOERS, LEANNE IDZERDA, JOHN R. KIRWAN, TORE K. KVIEN, PETER S. TUGWELL, MAXIME DOUGADOS
The Journal of Rheumatology Aug 2011, 38 (8) 1720-1727; DOI: 10.3899/jrheum.110392

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It's Good to Feel Better But It's Better To Feel Good and Even Better to Feel Good as Soon as Possible for as Long as Possible. Response Criteria and the Importance of Change at OMERACT 10
VIBEKE STRAND, MAARTEN BOERS, LEANNE IDZERDA, JOHN R. KIRWAN, TORE K. KVIEN, PETER S. TUGWELL, MAXIME DOUGADOS
The Journal of Rheumatology Aug 2011, 38 (8) 1720-1727; DOI: 10.3899/jrheum.110392
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OMERACT 10: 10th International Consensus Conference on Outcome Measures in Rheumatology, Kota Kinabalu, Borneo - May 4–8, 2010

  • The OMERACT Ultrasound Task Force — Status and Perspectives
  • Update on Research and Future Directions of the OMERACT MRI Inflammatory Arthritis Group
  • Patterns of Magnetic Resonance Imaging Bone Erosion in Rheumatoid Arthritis — Which Bones Are Most Frequently Involved and Show the Most Change?
Show more OMERACT 10: 10th International Consensus Conference on Outcome Measures in Rheumatology, Kota Kinabalu, Borneo - May 4–8, 2010

Patient-reported Outcomes

  • The OMERACT Ultrasound Task Force — Status and Perspectives
  • Update on Research and Future Directions of the OMERACT MRI Inflammatory Arthritis Group
  • Patterns of Magnetic Resonance Imaging Bone Erosion in Rheumatoid Arthritis — Which Bones Are Most Frequently Involved and Show the Most Change?
Show more Patient-reported Outcomes

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