Abstract
Objective. To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA).
Methods. Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed.
Results. Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA.
Conclusion. The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases.
Footnotes
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Supported by the US National Institutes of Health (grant AR-40857); the Work Environment Fund of Finland; the Academy of Finland (grants 38332 and 42044); the Alberta Heritage Foundation for Medical Research, Canada; the European Community’s Seventh Framework Programme (FP7, 2007-2013; grant HEALTH-F2-2008-201626; project GENODISC); Ministry of Education of Finland; the University of Jyväskylä; and the University of Kuopio. A. Näkki was supported by TULES Graduate School, TBGS National Graduate School of Musculoskeletal Disorders and Biomaterials, The Finnish Cultural Foundation, and The Otto A. Malm Foundation. The Finnish Twin Cohort Study is a project of the Academy of Finland Centre of Excellence in Complex Disease Genetics.
- Accepted for publication November 2, 2010.