Abstract
Objective. To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA).
Methods. A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology.
Results. No association was observed between ITGAM rs1143679 and GCA (p = 0.80, OR 0.97). Similarly, subphenotype analyses did not yield significant differences between the case subgroups and the control set or between GCA patients with or without the main specific features of GCA.
Conclusion. Our results suggest that the ITGAM rs1143679 variant does not play an important role in the pathophysiology of GCA.
Footnotes
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F.D. Carmona and A. Serrano share first authorship, and M.A. González-Gay and J. Martín share senior authorship of this report.
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Supported by Fondo de Investigaciones Sanitarias, grants PI06-0024 and PS09/00748 (Spain), and by RETICS Program RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII). F.D. Carmona was supported by Consejo Superior de Investigaciones Científicas (CSIC) through the JAE-DOC program.
- Accepted for publication July 21, 2011.