To the Editor:
A 57-year-old man had weekly to biweekly recurrent episodes of angioedema over 18 months, which resulted in 12 hospital admissions. He had had a seronegative arthritis compatible with psoriatic arthritis sine psoriasis for 4 years. His arthritis was active despite concomitant treatment with sulphasalzine and methotrexate. In addition, he suffered from hypercholesterolemia and hypertension, for which he was treated with rosuvastatin and lercanipidine. He suffered from ischemic heart disease and had transient cerebral ischemic attack. The episodes of angioedema were unrelated to his medications.
Laboratory investigation showed elevated creatine phosphokinase of 442 U/l (normal = 26–190 U/l), within normal levels of lipids including cholesterol, triglycerides, and high-density lipoprotein, normal levels of complement components including C1 inhibitor, C3 and C4, and normal bleeding time, normal …
Address correspondence to Dr. M. Rottem, Allergy, Asthma and Immunology Service, Emek Medical Center, Afula 18101, Israel. E-mail: menachem{at}rottem.net