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Abstract

Abnormal histone modification patterns in lupus CD4+ T cells.

Nan Hu, Xiangning Qiu, Yongqi Luo, Jun Yuan, Yaping Li, Wenzhi Lei, Guiying Zhang, Ying Zhou, Yuwen Su and Qianjin Lu
The Journal of Rheumatology May 2008, 35 (5) 804-810;
Nan Hu
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Xiangning Qiu
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Yongqi Luo
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Jun Yuan
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Yaping Li
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Wenzhi Lei
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Guiying Zhang
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Ying Zhou
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Yuwen Su
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Qianjin Lu
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Abstract

OBJECTIVE: To investigate alterations in histone modifications in patients with systemic lupus erythematosus (SLE). METHODS: Global histone H3/H4 acetylation and H3K4/H3K9 methylation in CD4+ T cells from 20 SLE patients and 10 healthy control subjects were assayed using the EpiQuik global histone H3/H4 acetylation and H3K4/H3K9 methylation assay kits. mRNA levels of 12 members of 3 classes of chromatin modifier genes were measured by real-time quantitative polymerase chain reaction. RESULTS: Global histone H3 and H4 hypoacetylation was observed in active lupus CD4+ T cells compared with controls (p = 0.002 and p = 0.009, respectively). The degree of histone H3 acetylation correlated negatively with increased disease activity in lupus patients as measured by SLEDAI (r = -0.889, p = 0.044). We found global histone H3K9 hypomethylation in both active and inactive lupus CD4+ T cells, compared with controls (p = 0.001, p = 0.003, respectively). However, global levels of H3K4 methylation were not different between patients and controls. SIRT1 mRNA levels were significantly increased in active lupus CD4+ T cells compared with controls (p < 0.001), while mRNA levels of CREBBP, P300, HDAC2, HDAC7, SUV39H2, and EZH2 were significantly downregulated in patients with active lupus (p < 0.001, p < 0.001, p = 0.01, p < 0.001, p = 0.003, p = 0.001, respectively). CONCLUSION: Histone modifications appear abnormal in CD4+ T cells in SLE.

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The Journal of Rheumatology
Vol. 35, Issue 5
1 May 2008
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Abnormal histone modification patterns in lupus CD4+ T cells.
Nan Hu, Xiangning Qiu, Yongqi Luo, Jun Yuan, Yaping Li, Wenzhi Lei, Guiying Zhang, Ying Zhou, Yuwen Su, Qianjin Lu
The Journal of Rheumatology May 2008, 35 (5) 804-810;

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Abnormal histone modification patterns in lupus CD4+ T cells.
Nan Hu, Xiangning Qiu, Yongqi Luo, Jun Yuan, Yaping Li, Wenzhi Lei, Guiying Zhang, Ying Zhou, Yuwen Su, Qianjin Lu
The Journal of Rheumatology May 2008, 35 (5) 804-810;
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