Excerpt
To the Editor:
Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disease characterized by arthralgias, transient cutaneous eruption, and high fluctuating fever1. No pathognomonic biological marker has yet been identified, making diagnosis difficult.
Recent pathophysiological findings showed thatAOSD is characterized by a particular cytokine profile, suggesting implication of Th1 immune response. The overwhelming implication of interleukin 1 (IL-1) in the systemic inflammatory reaction seen during the course of AOSD has justified the administration of agents blocking IL-1 receptor (anakinra), which gave some good results3,4. We describe a case of AOSD with an activated macrophage syndrome that responded to anakinra.…