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Abstract

Two cases of antinuclear antibody negative lupus showing increased proportion of B cells lacking RP105.

Syuichi Koarada, Masaru Ide, Yoshio Haruta, Yoshifumi Tada, Osamu Ushiyama, Fumitaka Morito, Akihide Ohta and Kohei Nagasawa
The Journal of Rheumatology March 2005, 32 (3) 562-564;
Syuichi Koarada
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Masaru Ide
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Yoshio Haruta
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Yoshifumi Tada
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Osamu Ushiyama
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Fumitaka Morito
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Akihide Ohta
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Kohei Nagasawa
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Abstract

B cells lacking RP105 molecule, a member of the Toll-like receptor family, were increased in the peripheral blood of 2 patients with antinuclear antibody (ANA) negative systemic lupus erythematosus (SLE). The increased proportion of RP105-lacking B cells was associated with disease activity in patients with ANA-negative SLE. When there are no significant serological markers for SLE, analysis of expression of RP105 may be helpful in evaluation of activity in ANA-negative SLE. We describe a new approach, using phenotyping of B cells, to evaluate activity of ANA-negative SLE.

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The Journal of Rheumatology
Vol. 32, Issue 3
1 Mar 2005
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Two cases of antinuclear antibody negative lupus showing increased proportion of B cells lacking RP105.
Syuichi Koarada, Masaru Ide, Yoshio Haruta, Yoshifumi Tada, Osamu Ushiyama, Fumitaka Morito, Akihide Ohta, Kohei Nagasawa
The Journal of Rheumatology Mar 2005, 32 (3) 562-564;

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Two cases of antinuclear antibody negative lupus showing increased proportion of B cells lacking RP105.
Syuichi Koarada, Masaru Ide, Yoshio Haruta, Yoshifumi Tada, Osamu Ushiyama, Fumitaka Morito, Akihide Ohta, Kohei Nagasawa
The Journal of Rheumatology Mar 2005, 32 (3) 562-564;
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Print ISSN: 0315-162X; Online ISSN: 1499-2752
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