%PDF-1.4
%
34 0 obj
<>
endobj
31 0 obj
<>
endobj
259 0 obj
<>stream
Acrobat Distiller 4.05 for Macintosh
2004-11-12T10:47Z
2024-03-28T16:12:14-07:00
QuarkXPressª 4.11: AdobePS 8.8.0 (301)
2024-03-28T16:12:14-07:00
application/pdf
Heather
2004-351.dec
uuid:f10a39c2-1dd1-11b2-0a00-960827bd3700
uuid:f10a39c4-1dd1-11b2-0a00-5b0000000000
endstream
endobj
20 0 obj
<>
endobj
21 0 obj
<>
endobj
35 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 10 0 R/Type/Page>>
endobj
1 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 12 0 R/Type/Page>>
endobj
4 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 14 0 R/Type/Page>>
endobj
271 0 obj
[276 0 R]
endobj
272 0 obj
<>stream
q
0 0 612 792 re
W n
BT
0.85091 0.85091 0.85091 rg
/T1_0 19 Tf
0.6229 0.7822 -0.7822 0.6229 12.739 54.1879 Tm
(Personal non-commercial use only. The Journal of Rheumatology. Copyright\
\251 2004. All rights reserved)Tj
ET
Q
1 g
/GS0 gs
0 792 m
0 792 l
f
q
12 789 587 -785 re
W n
q
0 792.03 612 -792 re
W n
0 0 0 1 K
/GS1 gs
53.46 77 m
558.47 77 l
S
0 0 0 0 k
52.32 70.16 64.18 -15.66 re
f*
BT
0 0 0 1 k
/T1_1 1 Tf
8 0 0 8 53.3216 57.2343 Tm
(2328)Tj
ET
0 0 0 0 k
355.5 70.16 203 -15.66 re
f*
BT
0 0 0 1 k
/T1_1 1 Tf
-0.00011 Tc 0.02499 Tw 8 0 0 8 419.8613 57.2343 Tm
(The Journal of Rheumatology 2004; 31:12)Tj
/T1_2 1 Tf
-43.3117 85.0369 Td
(onset of collagen-induced arthritis reduces joint inflammation,)Tj
0 -1.25 TD
[(cartilage destruction, and bone erosion. )55 (Arthritis Rheum)]TJ
0 Tc 0 Tw T*
(2004;50:650-9.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(13.)-875 (Liew FY)129 (, )18 (W)80 (ei X-Q, McInnes IB. Role of interleukin 18 in)]TJ
2.175 -1.25 Td
[(rheumatoid arthritis. )55 (Ann Rheum Dis 2003;62 Suppl II:ii48-ii50.)]TJ
-2.175 -1.25 Td
[(14.)-875 (Murphy CA, Langrish CL, Chen )37 (Y)129 (, et al. Diver)18 (gent pro- and)]TJ
2.175 -1.25 Td
(antiinflammatory roles for IL-23 and IL-12 in joint autoimmune)Tj
T*
(inflammation. J Exp Med 2003;198:1951-7.)Tj
-2.175 -1.25 Td
[(15.)-875 (W)80 (ong PKK, Campbell IK, Egan PJ, Ernst M, )18 (W)40 (icks IP)111 (. )18 (The role of)]TJ
2.175 -1.25 Td
(interleukin-6 family of cytokines in inflammatory arthritis and bone)Tj
T*
[(turnover)55 (. )55 (Arthritis Rheum 2003;48:1)37 (177-89.)]TJ
-2.175 -1.25 Td
[(16.)-875 (Choy EH, Isenber)18 (g DA, Garrood )18 (T)74 (, et al. )18 (Therapeutic benefit of)]TJ
2.175 -1.25 Td
(blocking interleukin-6 activity with an anti-interleukin-6 receptor)Tj
T*
(monoclonal antibody in rheumatoid arthritis: a randomized, double-)Tj
T*
[(blind, placebo-controlled, dose-escalation trial. )55 (Arthritis Rheum)]TJ
0 Tc 0 Tw T*
(2002;46:3143-50.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(17.)-875 (Langdon C, Leith J, Smith F)80 (, Richards CD. Oncostatin M)]TJ
2.175 -1.25 Td
(stimulates monocyte chemoattractant protein-1 and interleukin-1-)Tj
T*
(induced matrix metalloproteinase-1 production by human synovial)Tj
T*
[(fibroblasts in vitro. )55 (Arthritis Rheum 1997;40:2139-46.)]TJ
-2.175 -1.25 Td
[(18.)-875 (Rowan )55 (AD, Koshy PJ, Shingleton )18 (WD, et al. Syner)18 (gistic ef)18 (fects of)]TJ
2.175 -1.25 Td
(glycoprotein 130 binding cytokines in combination with)Tj
T*
[(interleukin-1 on cartilage collagen breakdown. )55 (Arthritis Rheum)]TJ
0 Tc 0 Tw T*
(2001;44:1620-32.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(19.)-875 (Koshy PJT)74 (, Lundy CJ, Rowan )55 (AD, et al. )18 (The modulation of matrix)]TJ
2.175 -1.25 Td
[(metalloproteinase and )55 (ADAM gene expression in human)]TJ
T*
[(chondrocytes by interleukin-1 and oncostatin M. )55 (Arthritis Rheum)]TJ
0 Tc 0 Tw T*
(2002;46:961-7.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(20.)-875 (Koshy PJ, Henderson N, Logan C, Life PF)80 (, Cawston )18 (TE, Rowan)]TJ
2.175 -1.25 Td
(AD. Interleukin 17 induces cartilage collagen breakdown: novel)Tj
33 36.25 Td
[(syner)18 (gistic ef)18 (fects in combination with proinflammatory cytokines.)]TJ
0 Tc T*
(Ann Rheum Dis 2002;61:704-13.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(21.)-875 (Li )18 (WQ, Dehnade F)80 (, Zafarullah M. Oncostatin M-induced matrix)]TJ
2.175 -1.25 Td
(metalloproteinase and tissue inhibitor of metalloproteinase-3 genes)Tj
T*
[(expression in chondrocytes requires Janus kinase/ST)80 (A)111 (T)-257 (signaling)]TJ
T*
[(pathway)65 (. J Immunol 2001;166:3491-8.)]TJ
-2.175 -1.25 Td
[(22.)-875 (Langdon C, Kerr C, Hassen M, Hara )18 (T)74 (, )55 (Arsenault )55 (AL, Richards)]TJ
2.175 -1.25 Td
(CD. Murine oncostatin M stimulates mouse synovial fibroblasts in)Tj
T*
(vitro and induces inflammation and destruction in mouse joints in)Tj
T*
[(vivo. )55 (Am J Pathol 2000;157:1)37 (187-96.)]TJ
-2.175 -1.25 Td
[(23.)-875 (de Hooge )55 (ASK, van de Loo F)74 (AJ, Bennink M, et al. Growth plate)]TJ
2.175 -1.25 Td
(damage, a feature of juvenile idiopathic arthritis, can be induced by)Tj
T*
[(adenoviral gene transfer of oncostatin M. )55 (Arthritis Rheum)]TJ
0 Tc 0 Tw T*
(2003;48:1750-61.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(24.)-875 (Rowan )55 (AD, Hui )18 (W)92 (, Cawston )18 (TE, Richards CD. )55 (Adenoviral gene)]TJ
2.175 -1.25 Td
(transfer of interleukin-1 in combination with oncostatin M induces)Tj
T*
[(significant joint damage in a murine model. )55 (Am J Pathol)]TJ
0 Tc 0 Tw T*
(2003;162:1975-84.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(25.)-875 (Hui )18 (W)92 (, Rowan )55 (AD, Richards CD, Cawston )18 (TE. Oncostatin M in)]TJ
2.175 -1.25 Td
(combination with tumour necrosis factor induces cartilage damage)Tj
T*
(and matrix metalloproteinase expression in vitro and in vivo.)Tj
T*
(Arthritis Rheum 2003;48:3404-18.)Tj
-2.175 -1.25 Td
[(26.)-875 (Plater)20 (-Zyberk C, Buckton J, )18 (Thompson S, et al. )55 (Amelioration of)]TJ
2.175 -1.25 Td
(arthritis in two murine models using antibodies to oncostatin M.)Tj
T*
(Arthritis Rheum 2001;44:2697-702.)Tj
-2.175 -1.25 Td
[(27.)-875 (T)70 (anaka M, Hirabayashi )37 (Y)129 (, Sekiguchi )18 (T)74 (, Inoue )18 (T)74 (, Katsuki M,)]TJ
2.175 -1.25 Td
[(Miyajima )55 (A. )18 (T)70 (ar)18 (geted disruption of oncostatin M receptor results in)]TJ
T*
(altered hematopoiesis. Blood 2003;102:3154-62.)Tj
ET
0 0 0 0 k
/GS0 gs
111.09 82.75 407.5 -10.83 re
f*
0.5 w
111.09 82.75 407.5 -10.83 re
S
Q
Q
q
1 0 0 1 13 2 cm
0 0 612 792 re
W n
1 0 0 1 -13 -2 cm
BT
0 0 0 rg
ET
/GS2 gs
BT
/T1_3 8 Tf
125.368 75 Td
(Personal, non-commercial use only. The Journal of Rheumatology. Copyri\
ght \251 2004. All rights reserved.)Tj
ET
Q
BT
0 g
/GS3 gs
/T1_4 1 Tf
10 0 0 10 540 17 Tm
( )Tj
0 0.48627 0.77255 rg
/GS3 gs
-7.22298 0 Td
(www.jrheum.org)Tj
0 g
/GS3 gs
-16.72996 0 Td
(Downloaded on March 28, 2024 from )Tj
ET
endstream
endobj
14 0 obj
<>stream
8;Z\76'B,>#ikq,j?),9J:qDoBtD%FU0n*ekJpU[^^,*&kV
iqs$::.5]T5aSE\lQ2!_/RqtI(=d:A"78_\AQ\UP;;>fIToqHB'5kn.@R@1Qm3(M!
k@DN%'ZnO%9l`ULkilV\=/QOcd5="n2[\gg%7p7QW/_5/M*aef:@W1\(i^"!-AHr0
Q9^kN0%IVcSd'-J/A?neIaj'%l+R6W.XK13AQ^_ce2F59,WLIs5/L,^BF!U/8UYT`
0W$M3s+]8N1e%`Q!/@Ihbf3],d2Nd-7Iae;]kAmd#JAAPMbfg8gulf5e#;'R*qlFp
c(5IqQp)j)-Xs>_Il*@*2S&d,Qk"ccMO)_PVgTZDjeLEJ14ifG'FEg;V[2t/YRYC,
eqq/ZFo/s2r![WGm,HGr7Q*_ZTCc=YMHshHmhUh)+j6D:lGkio>sHco1n,$1CDjcW
OgSf;:2,
endstream
endobj
18 0 obj
[/Indexed/DeviceRGB 255 17 0 R]
endobj
17 0 obj
<>stream
J,g]g+e/h_!_gCtO=0f)$P%cIi8Zdfc5&3j_8$7g.@L`YKUJNGBP\poR=_;Dl'P(T
(7Boo^^S:71(MN]ZQX/+Cbu.lK"p74pe1T%s.DY%&\1TdJhr54.M9au6>79n6`Q:4
PbLSZTLEE(8E@'*1mg_*eTnN*;*'V3+gm-EEetX%;Bo$ur2ss*N`.-!.kG_q6GDD'
dKoL!8Ka#EV,@V!\j8ZFbp6EE<9cn=N6j0nf;(&;QU6bUD')c@\
9-d\DA=cZ0Q>gIM$$;cd2O@&a;X,Nn_aP(]I1aRc(K1^ue>
gF/(+GaKo$qneLWDrQ#;5\S(\$q'4Q,85`-8;S(=Z"WSBOV*FM)4,?B],R
endstream
endobj
82 0 obj
<>
endobj
37 0 obj
<>
endobj
49 0 obj
<>
endobj
75 0 obj
<>
endobj
265 0 obj
<>
endobj
48 0 obj
<>
endobj
62 0 obj
<>stream
HtTTaEYeWg6GDDQ5A6|vӨ ES\`XP4E5*=o6v =mi;s;3oλι$,-$ᡁ!WhItڡ,^IcI~R%RYjsR_ bKȿZb8mF*/"N.isfTWi~CNWbԪDjv.%ITTX*EWa*^JMU'FītkIjUU6v.Ep&VQs?&H$HƖPxG"ȑDA,"(BD+Sb%7mnk-)*zjj(TTFL]b?> !()<2Xb#vx+]$-̷y,(밵ͳ}?g䑑GY%۵Y^yZ0:OnyFN=8F?qO*J&sl~Fuc08qTn>8 DȂ_HXL| Po0_l3 UTdpKtb*.d\
MOS'ne*(R
wl\A6B!b*S0j˒O$%pHkLjABs(¿UdỴ?á@_,4:c0zf i$RXF>BAW!n87ע+/6[B 2Q6fXo
_,
YC)~5Pxî@%jhWo/yx㊲(`KrDKM_[;!mQ01X,:C
;X-o
LK[Cݽs{7--"CMk[G>'lwѭSk9WsۊG{;@ɻC&A #9_[KE&Ȇ~qo<&|/ӗ/Jؙ4#70ǐv;sz+