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(changes)Tj
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(22)Tj
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[(. )17.7 (These findings, together with the relatively short)]TJ
0.32401 Tw -3.8704 -1.2 Td
(disease duration \(3 years\), would suggest a low grade)Tj
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[(inflammatory process. )17.7 (This picture is similar to the synovial)]TJ
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(19)Tj
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(,)Tj
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[(termed familial arthritis and camptodactyly; however)39.7 (, their)]TJ
0.0246 Tw T*
(cases had autosomal dominant inheritance, and iridocyclitis)Tj
0.0376 Tw T*
(was present in 2 of them. Ochi, )Tj
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(et al)Tj
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(cited that early in the)Tj
0.1299 Tw -15.4088 -1.2 Td
(disease, there is early and persistent low grade inflamma-)Tj
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(tion, followed by degeneration of tendons that are later)Tj
0.1006 Tw T*
[(replaced by fibrous tissue. )17.7 (Therefore, it might be assumed)]TJ
0.1263 Tw T*
(that these 2 cases would represent the early inflammatory)Tj
0.0197 Tw T*
(stage of disease, while other cases \(with disease duration of)Tj
0.02499 Tw T*
(7\32017 yrs\) represent the late postinflammatory stage.)Tj
0.16071 Tw 1.2 -1.18 Td
[(No case with pericarditis was found in our study)64.8 (. )17.8 (The)]TJ
-0.03619 Tw -1.2 -1.18 Td
[(term CACP)-177.1 (syndrome was used to verify that camptodactyly)]TJ
0.3405 Tw 0 -1.18 TD
(and noninflammatory arthropathy when associated with)Tj
-0.01601 Tw T*
(either coxa vara or pericarditis constitute a single syndrome.)Tj
0.1402 Tw T*
(Noninflammatory pericarditis has been described in up to)Tj
0.1559 Tw T*
(30% of published cases)Tj
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(4,7,8,10)Tj
-0.00011 Tc 0.15581 Tw 10 0 0 10 173.9334 350.4552 Tm
(. Indeed, pericarditis may be)Tj
0.31799 Tw -11.9933 -1.18 Td
(mild and self-limited)Tj
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(11)Tj
-0.00011 Tc 0.31799 Tw 10 0 0 10 150.357 338.6552 Tm
(, or life-threatening, necessitating)Tj
0.32651 Tw -9.6357 -1.18 Td
(pericardiocentesis or pericardiotomy)Tj
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(4,7,8,10)Tj
-0.00011 Tc 0.30881 Tw 10 0 0 10 228.2453 326.8552 Tm
[(. Therefore, )-17.7 (all)]TJ
0.00349 Tw -17.4245 -1.18 Td
[(cases with this syndrome should be observed for emer)17.7 (gence)]TJ
0.02499 Tw T*
(of other features of pericardial disease.)Tj
-0.0051 Tc 0.0513 Tw 1.2 -1.17 Td
[(W)79.9 (e describe 10 cases, which is a relatively lar)17.6 (ge number)]TJ
0.0361 Tw -1.2 -1.17 Td
[(with camptodactyly and noninflammatory arthropathy)64.7 (. Such)]TJ
0.01489 Tc 0.3978 Tw 0 -1.17 TD
(a syndrome is clearly distinct from other childhood)Tj
-0.0051 Tc -0.0204 Tw T*
(arthropathies. Cases referred as juvenile rheumatoid arthritis,)Tj
-0.0175 Tw T*
(in particular with abnormal presentation or with lack of overt)Tj
0.0484 Tw T*
(clinical or laboratory evidence of inflammation, ought to be)Tj
0.1516 Tw T*
(thoroughly investigated. MRI would be considered among)Tj
0.192 Tw T*
[(the investigative tools that can dif)17.6 (ferentiate the syndrome)]TJ
0.02499 Tw T*
(from other childhood connective tissue diseases.)Tj
/T1_2 1 Tf
-0.00011 Tc 0 Tw 0 -2.4 TD
(REFERENCES)Tj
/T1_0 1 Tf
0.02499 Tw 8 0 0 8 61 163.9552 Tm
[(1.)-875.1 (Jacobs JC. \322E\323 familial arthritis. Proceedings of the 1)36.8 (1th)]TJ
1.675 -1.25 Td
(International Congress on the Rheumatic Diseases; 1965 Dec; Mar)Tj
0 -1.25 TD
[(del Plata, )54.8 (Ar)17.7 (gentina. Quoted from Jacobs JC, Downy JA. Juvenile)]TJ
T*
[(rheumatoid arthritis. In: Downy JA, Low NL, editors. )17.7 (The child)]TJ
T*
[(with disabling illness. Philadelphia: )17.7 (WB Saunders; 1974:5-24. )]TJ
-1.675 -1.25 Td
[(2.)-875.1 (Didier R. Maladie synoviale familiale. )54.8 (Arch Fr Pedatr 1953;)]TJ
0 Tc 0 Tw 1.675 -1.25 Td
(10:319-21.)Tj
-0.00011 Tc 0.02499 Tw -1.675 -1.25 Td
[(3.)-875.1 (Athreya BH, Schumacher HR. Pathologic features of a familial)]TJ
1.675 -1.25 Td
(arthropathy associated with congenital flexion contractures of)Tj
T*
[(fingers. )54.8 (Arthritis Rheum 1978;21:429-37.)]TJ
31.325 80.0718 Td
[(4.)-875.1 (Martinez-Lavin M, Buendia )54.8 (A, Delgado E, et al. )54.8 (A)-220.1 (familial)]TJ
1.675 -1.25 Td
[(syndrome of pericarditis, arthritis, and camptodactyly)64.8 (. N Engl J)]TJ
0 Tc T*
(Med 1983;309:224-5.)Tj
-0.00011 Tc -1.675 -1.25 Td
[(5.)-875.1 (Ochi )17.7 (T)74 (, Iwase R, Okabe N, Fink CW)91.7 (, Ono K. )17.7 (The pathology of the)]TJ
1.675 -1.25 Td
(involved tendons in patients with familial arthropathy and )Tj
T*
[(congenital camptodactyly)64.9 (. )54.8 (Arthritis Rheum 1983;26:896-900.)]TJ
-1.675 -1.25 Td
[(6.)-875.1 (Martin JR, Huang S-N, Lacson )54.8 (A, et al. Congenital contractural)]TJ
1.675 -1.25 Td
[(deformities of the fingers and arthropathy)64.8 (. )54.8 (Ann Rheum Dis)]TJ
0 Tc 0 Tw T*
(1985;44:826-30.)Tj
-0.00011 Tc 0.02499 Tw -1.675 -1.25 Td
[(7.)-875.1 (Bulutlar G, )36.8 (Y)99.8 (azici H, Ozdogan H, Schreuder I. )54.8 (A)-220.1 (familial syndrome)]TJ
1.675 -1.25 Td
[(of pericarditis, arthritis, camptodactyly)64.8 (, and coxa vara. )54.8 (Arthritis)]TJ
0 Tc T*
(Rheum 1986;29:436-8.)Tj
-0.00011 Tc -1.675 -1.25 Td
[(8.)-875.1 (Laxer RM, Cameron BJ, Chaisson D, Smith CR, Stein LD. )17.7 (The)]TJ
1.675 -1.25 Td
(camptodactyly-arthropathy-pericarditis syndrome: case report and)Tj
T*
[(literature review)64.8 (. )54.8 (Arthritis Rheum 1986;29:439-44.)]TJ
-1.675 -1.25 Td
[(9.)-875.1 (Bahabri S, Sakati N, Hugosson C, et al. Syndrome of )]TJ
1.675 -1.25 Td
[(camptodactyly)64.8 (, arthropathy and coxa vara \(CAC syndrome\). )54.8 (Ann)]TJ
0 Tc T*
(Saudi Med 1994;14:479-82.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(10.)-875.1 (V)110.8 (erma UN, Misra R, Radhakrisnan S, Maitra SC, )54.8 (Agarwal SS,)]TJ
2.175 -1.25 Td
[(Singh RR. )54.8 (A)-220.1 (syndrome of fibrosing pleuritis, pericarditis, and)]TJ
T*
(synovitis with infantile contractures of fingers and toes in 2 sisters:)Tj
T*
(\322familial fibrosing serositis.\323 J Rheumatol 1995;22:2349-55.)Tj
-2.1381 -1.25 Td
[(1)36.8 (1)-0.1 (.)-875.1 (Bahabri SA, Suwairi )17.7 (WM, Laxer RM, Polinkovsky )54.8 (A, Dalaan )54.8 (AA,)]TJ
2.1381 -1.25 Td
[(W)79.9 (arman ML. )17.7 (The camptodactyly-arthropathy-coxa vara-pericarditis)]TJ
T*
(syndrome. Clinical features and genetic mapping to human )Tj
T*
[(chromosome 1. )54.8 (Arthritis Rheum 1998;41:730-5. )]TJ
-2.175 -1.25 Td
[(12.)-875.1 (Faivre L, Prieur )54.8 (AM, Le Merrer M, et al. Clinical variability and)]TJ
2.175 -1.25 Td
(genetic homogeneity of the camptodactyly-arthropathy-coxa )Tj
T*
[(vara-pericarditis syndrome. )54.8 (Am J Med Genet 2000;95:233-6.)]TJ
-2.175 -1.25 Td
[(13.)-875.1 (Marcelino J, Carpten JD, Suwairi )17.7 (WM, et al. CACP)110.7 (, encoding a)]TJ
2.175 -1.25 Td
(secreted proteoglycan, is mutated in camptodactyly-arthropathy-)Tj
T*
(coxa vara-pericarditis syndrome. Nat Genet 1999;23:319-22.)Tj
-2.175 -1.25 Td
[(14.)-875.1 (Flannery CR, Hughes CE, Schumacher BL, et al. )54.7 (Articular cartilage)]TJ
2.175 -1.25 Td
(superficial zone protein \(SZP\) is homologous to megakaryocyte)Tj
T*
(stimulating factor precursor and is a multifunctional proteoglycan)Tj
T*
(with potential growth-promoting, cytoprotective, and lubricating)Tj
T*
(properties in cartilage metabolism. Biochem Biophys Res Commun)Tj
0 Tc 0 Tw T*
(1999;254:535-41.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(15.)-875.1 (Jay GD, Britt DE, Cha CJ. Lubricin is a product of megakaryocyte)]TJ
2.175 -1.25 Td
(stimulating factor gene expression by human synovial fibroblasts. )Tj
T*
(J Rheumatol 2000;27:594-600. )Tj
-2.175 -1.25 Td
[(16.)-875.1 (W)79.9 (arman ML. Human genetic insights into skeletal development,)]TJ
2.175 -1.25 Td
(growth, and homeostasis. Clin Orthop 2000;379 Suppl:S40-54.)Tj
-2.175 -1.25 Td
[(17.)-1150.1 (Su JL, Schumacher BL, Lindley KM, et al. Detection of superficial)]TJ
2.175 -1.25 Td
(zone protein in human and animal body fluids by cross-species)Tj
T*
(monoclonal antibodies specific to superficial zone protein.)Tj
T*
(Hybridoma 2001;20:149-57.)Tj
-2.175 -1.25 Td
[(18.)-875.1 (Engber )17.7 (WD, Flatt )54.8 (AE. Camptodactyly: an analysis of sixty-six)]TJ
2.175 -1.25 Td
[(patients and twenty-four operations. J Hand Sur)17.7 (g 1977;2:216-24.)]TJ
-2.175 -1.25 Td
[(19.)-875.1 (Malleson P)110.7 (, Schaller JG, Dega F)79.7 (, Cassidy SB, Pagon RA. Familial)]TJ
2.175 -1.25 Td
[(arthritis and camptodactyly)64.8 (. )54.8 (Arthritis Rheum 1981;24:1)36.8 (199-204.)]TJ
-2.175 -1.25 Td
[(20.)-875.1 (Hammoudeh M, Siam )54.8 (AR. Familial hypertrophic synovitis. Clin)]TJ
2.175 -1.25 Td
(Rheumatol 1993;12:401-4.)Tj
-2.175 -1.25 Td
[(21.)-875.1 (Hugosson C, Bahabri S, McDonald P)110.7 (,)-0.1 ( )54.8 (Al-Dalaan )54.8 (A, )54.8 (Al-Mazyed )54.8 (A.)]TJ
2.175 -1.25 Td
[(Radiological features in congenital camptodactyly)64.8 (, familial)]TJ
T*
(arthropathy and coxa vara syndrome. Pediatr Radiol 1994;24:523-6.)Tj
-2.175 -1.25 Td
[(22.)-875.1 (Herve-Somma CMP)110.7 (, Sebag GM, Prieur )54.8 (AM, Bonnerot )17.7 (V)128.9 (,)]TJ
2.175 -1.25 Td
[(Lallemand DP)110.7 (. Juvenile rheumatoid arthritis of the knee: MR )]TJ
0 Tc T*
[(evaluation with Gd-DOT)79.8 (A. Radiology 1992;182:93-8.)]TJ
-0.00011 Tc -2.175 -1.25 Td
[(23.)-875.1 (Eich GF)79.7 (, Halle F)79.7 (, Hodler J, Segar R, )17.7 (W)39.9 (illi UV)128.8 (. Juvenile chronic)]TJ
2.175 -1.25 Td
(arthritis: imaging of the knees and hips before and after )Tj
T*
(intraarticular steroid injection. Pediatr Radiol 1994;24:558-63.)Tj
-2.175 -1.25 Td
[(24.)-875.1 (Cohen PT)73.9 (, Job-Deslandre CH, Lalande G, )54.8 (Adamsbaum C.)]TJ
2.175 -1.25 Td
(Overview of the radiology of juvenile idiopathic arthritis. Eur J)Tj
0 Tc T*
(Radiol 2000;33:94-101.)Tj
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(\002\003\003\004\005\006\004\003\005")Tj
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/CS0 CS 0 0 0 1 SCN
54 54 m
558 54 l
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/T1_1 1 Tf
0.02499 Tw 8 0 0 8 424.3613 35.9844 Tm
(The Journal of Rheumatology 2003; 30:5)Tj
0 Tc 0 Tw -46.2952 -0.0313 Td
(1086)Tj
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0 0 0 0 scn
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109.25 59.1 396.47 -10.84 re
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0.5 w
109.25 59.1 396.47 -10.84 re
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0.0313 TL /Fm0 Do
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0 0 0 1 scn
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/T1_1 1 Tf
-0.00011 Tc -0.02521 Tw 8 0 0 8 56 595.5322 Tm
[(Figur)36.8 (e 8.)]TJ
/T1_0 1 Tf
3.8841 0 Td
(Distribution of camptodactyly in a boy \(right\) and in his younger)Tj
-0.0002 Tc 0 Tw -3.8841 -1.25 Td
[(sister)54.7 (.)]TJ
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117.48 51 Td
(Personal, non-commercial use only. The Journal of Rheumatology Copyrig\
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